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  4. Recombinant Rat Growth factor receptor-bound protein 10 (Grb10)

Recombinant Rat Growth factor receptor-bound protein 10 (Grb10)

  • 中文名称：
    大鼠Grb10重组蛋白
  • 货号：
    CSB-YP009887RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grb10重组蛋白
  • 货号：
    CSB-EP009887RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grb10重组蛋白
  • 货号：
    CSB-EP009887RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grb10重组蛋白
  • 货号：
    CSB-BP009887RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grb10重组蛋白
  • 货号：
    CSB-MP009887RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Grb10Growth factor receptor-bound protein 10; GRB10 adapter protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-599
  • 氨基酸序列
    MNNDINSSVE SLNSACNMQS DTDTVPLLEN GQSASNQPSA SSSRGQPQAS PRQKMQRSQP VHIQPLRRLQ EEDQQLRTSS LPAIPNPFPE LAGGAPGSPP SVAPSSLPPP PSQPPAKHFP PGFQLAKLTR PGLWTKTTAR FSKRQPKNQC QTDTANAVSR IPTSQMEKLR LRKDVKVFSE DGTSKVVEIL TDMTARDLCQ LLVYKSHCVD DNSWTLVEHH PQLGLERCLE DHEIVVQVES TMPSESKFLF RKNYAKYEFF KNPVNFFPDQ MVTWCQQSNG GQAQLLQNFL NSSSCPEIQG FLQVKEVGRK SWKKLYVCLR RSGLYYSTKG TSKEPRHLQL LADLEESSIF YLIAGKKQYN APNEHGMCIK PNKAKIEMKE LRLLCAEDEQ IRTCWMTAFR LLKYGMLLYQ NYRIPQQRKG LAPPFNAPMR SVSENSLVAM DFSGQIGRVI DNPAEAQSAA LEEGHAWRKR STRMNILSSQ SPLHPSTLNS VIHRTQHWFH GRISREESHR IIKQQGLVDG LFLLRDSQSN PKAFVLTLCH QQKIRNFQIL PCEDDGQTFF TLDDGNTKFS DLIQLVDFYQ LNKGVLPCKL KHHCIRVAL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.
  • 基因功能参考文献：
    1. In rat uterus, enforced miR199a expression suppresses cell proliferation partially through targeting Grb10. PMID: 24149516
    2. findings indicate that endogenous overexpression of Grb10 functions as a suppressor of the IGF1-IR pathway, which may represent an important mechanism for regulating cognitive disorder in diabetes PMID: 23614367
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GRB7/10/14 family
  • 数据库链接：

    STRING: 10116.ENSRNOP00000048487

    UniGene: Rn.63942