Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Gamma-aminobutyric acid receptor subunit alpha-4 (Gabra4), partial

Recombinant Rat Gamma-aminobutyric acid receptor subunit alpha-4 (Gabra4), partial

  • 中文名称：
    大鼠Gabra4重组蛋白
  • 货号：
    CSB-YP009143RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Gabra4重组蛋白
  • 货号：
    CSB-EP009143RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Gabra4重组蛋白
  • 货号：
    CSB-EP009143RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Gabra4重组蛋白
  • 货号：
    CSB-BP009143RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Gabra4重组蛋白
  • 货号：
    CSB-MP009143RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabra4
  • Uniprot No.：
  • 别名：
    Gabra4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. spontaneous, recurrent seizures that define chronic epilepsy may influence changes in GABAA receptor alpha4 expression PMID: 25223733
    2. The expression of Gabra4 in neonatal hippocampus was chaged in response to alterations in neurosteroid levels. PMID: 24011224
    3. alpha4betadelta GABA receptors play a role in mood and cognition at puberty in female mice. PMID: 23079628
    4. Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABAA receptor alpha4 subunit at the plasma membrane of hippocampal CA1 spines PMID: 22213233
    5. No change in alpha 4 subunit expression was seen in hippocampi of controlled cortical impact and post-traumatic epilepsy groups. PMID: 21439793
    6. Ethanol-induced increases in GABA(A) receptor alpha4 subunit expression in cerebral cortical neurons appear to be selectively mediated by protein kinase C (PKC)gamma and not PKCbeta. PMID: 21155805
    7. sex differences in the acoustic startle response were paralleled by sex differences in the expression of the GABAA-R alpha4 subunit in the amygdala PMID: 12581182
    8. Increased expression of GABA(A) receptor alpha 4 subunit in the interneurones of the periaqueductal gray matter could render the panic circuitry abnormally excitable by disinhibiting ongoing GABAergic inhibition. PMID: 15708482
    9. early growth response 3 as a major regulator of GABRA4 in developing neurons and in epilepsy PMID: 16091474
    10. These observations are the first molecular and functional evidence that show a selective inhibition by flumazenil of the up-regulation of alpha(4)-subunit expression elicited by ethanol withdrawal. PMID: 17403139
    11. In epileptic DGCs, the neurosteroid modulation of synaptic currents is diminished and alpha4 subunit-containing receptors are present at synapses and participate in synaptic transmission. PMID: 18003843
    12. Expression of the GABA(A) receptor alpha4 subunit mRNA increases two-fold in animals conditioned to chronic hypobaric hypoxia for 7 days PMID: 18056985
    13. Upregulation of the alpha 4-subunit was observed in the CA1 of nonresponders. Our data suggest that alterations in GABA(A) receptor subtypes may be involved in resistance to AEDs. PMID: 18562204
    14. Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. PMID: 19144854

    显示更多

    收起更多

  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA4 sub-subfamily
  • 数据库链接：

    KEGG: rno:140675

    STRING: 10116.ENSRNOP00000003191

    UniGene: Rn.81205