Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Endothelin B receptor (Ednrb), partial

Recombinant Rat Endothelin B receptor (Ednrb), partial

  • 中文名称：
    大鼠Ednrb重组蛋白
  • 货号：
    CSB-YP007404RA1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ednrb重组蛋白
  • 货号：
    CSB-EP007404RA1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ednrb重组蛋白
  • 货号：
    CSB-EP007404RA1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ednrb重组蛋白
  • 货号：
    CSB-BP007404RA1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ednrb重组蛋白
  • 货号：
    CSB-MP007404RA1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ednrb; Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. high glucose upregulated ETB receptors by downregulating Sirt1 and subsequently activating the ERK1/2 signaling pathways in the organ culture superior mesenteric arteries . PMID: 29115394
    2. The results presented herein show that ETB receptors (R) have much weaker Ca(2+)-sensitizing effect than ETA-R and that ETB-R appear to be more dependent on Ca(2+) influx presumably through voltage-gated Ca(2+) channels (VGCC). PMID: 28757442
    3. the mRNA expression of prepro-endothelin-1 (ppET-1), as well as that of the ETA and ETB receptors, were quantified by real-time PCR in these veins... exercise training mobilizes endothelin-1 (ET-1) to reinforce the Ang II-induced responses mainly through ETA activation PMID: 28012855
    4. Denervation reduced mean arterial pressure in ETB-deficient rats compared with sham-operated controls, however denervation did not affect the increase in blood pressure after 2 wk of high-salt diet. Denervation reduced cardiac sympathetic-to-parasympathetic tone [low frequency-high frequency (LF/HF)] during normal salt diet and vasomotor LF/HF tone during high-salt diet in ETB-def rats. PMID: 28701323
    5. Expression of smooth muscle proteins and both ETA and ETB by the endovascular trophoblast enable it to contract upon activation of both receptors by ET1. PMID: 27697218
    6. Data analyses strongly suggest that the identified deletion in the intergenic region upstream of Ednrb, which might contain a melanocyte-specific enhancer, is the mutation causative of the head spot phenotype in the KFRS4/Kyo rat strain. PMID: 28356074
    7. Used Western blots to characterize antibodies targeted to the N or C terminal and the second or third intracellular loop of the endothelin B receptor (ETB). The IL2-targeted antibody accurately detected endogenous ETB expression in brain and cultured astrocytes by labeling a 50-kDa band, the expected weight of full-length ETB. PMID: 25232999
    8. These findings demonstrate that diurnal excretion of an acute salt load 1) requires ET-1 and the ETB receptor, 2) is more evident in male vs. female rats, and 3) is opposed by the ETA receptor. PMID: 27582096
    9. Results suggest that endothelin receptor B (EDNRB) mutation reduces cell proliferation and increases apoptosis in the hippocampal formation of the spotting lethal rat, but does not alter the levels of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor. Our findings provide an insight into the cellular changes in the brains of Hirschsprung's disease patients caused by EDNRB mutation. PMID: 27017960
    10. both ETA and ETB receptor expression in the renal cortex were significantly attenuated by ovariectomy, and this reduction was not evident in OVX+E2 rats. SIGNIFICANCE: These data suggest that ovarian hormones regulate ET receptor expression and may contribute to sex differences in cardiovascular and renal health. PMID: 26776836
    11. a modified locus on Chromosome 7 was mainly responsible for the variance of pigmentary disorder between AGH-Ednrb(sl) rats and LEH-Ednrb(sl) rats, and two modifier loci showing epistatic interaction may, in part, influence pigment phenotype. PMID: 26796131
    12. Confirm the presence of ETA-ETB receptor cross-talk in the rat basilar artery. PMID: 26528589
    13. Results indicate that ETB receptors appear to play a role in the development of the central nervous system PMID: 25806822
    14. Results suggest that status epilepticus-induced ETB receptor/eNOS-mediated MMP-9 activation may lead to impairments of endothelial cell function via tight junctions protein degradation PMID: 26232046
    15. data suggest that ET receptors may be an important actor in diabetes-related liver damage. PMID: 24918345
    16. Findings indicate that the endothelin B receptor may be a novel therapeutic target for Alzheimer's disease and other neurovascular degenerative disorders. PMID: 26022359
    17. Physiologically relevant concentrations of ET-1/ET-3 did not modulate ET-B receptor function. PMID: 25891848
    18. Data show that the protein expression of the endothelin receptors ETA and ETB was significantly elevated in male growth-restricted offspring. PMID: 26459423
    19. Endothelin-B receptors modulate sympathetic activation during acute myocardial infarction not only in the ventricular myocardium, but also in the adrenal gland. PMID: 24503339
    20. The aim was to quantify the density of ETA and ETB receptors in cardiopulmonary tissue from pulmonary arterial hypertension patients and the monocrotaline (MCT) rat. PMID: 24582810
    21. ETB receptors in the cerebral cortex and subventricular zones of the brain decrease with age. PMID: 24815227
    22. Enhanced vascular expression of ETB receptors contributes to augmented ROS production, endothelial dysfunction and increased vasoconstriction in erectile tissue from insulin-resistant obese rats. PMID: 25091502
    23. Mitogen-activating protein kinases (ERK1/2 and p38) and the downstream transcriptional factor NF-kappaB pathways were involved in cyclosporin A-induced upregulation of ETB receptor in arterial smooth muscle cells. PMID: 25772258
    24. Renal expression of Ednrb correlated with captopril-induced blood pressure effects. PMID: 24779608
    25. Heart ischaemia-reperfusion induces local up-regulation of vasoconstrictor endothelin ETB receptors in rat coronary arteries downstream of occlusion. PMID: 24467585
    26. These findings identify a novel mechanistic interaction between the ET-1/ETB receptor axis and CX3CL1/CX3CR1 in mediating pulmonary angiogenesis and vascular monocyte accumulation in experimental HPS. PMID: 24731444
    27. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. PMID: 24914193
    28. Data from in vitro study on mesenteric microvessels suggest that up-regulation of endothelial ETBR/Ednrb (not ETAR/Ednra) contributes to enhanced microvascular relaxation, decreased vasoconstriction, and reduced vascular resistance during pregnancy. PMID: 23646960
    29. ETB receptors contribute to contraction and are coupled to the augmented ET-1 induced calcium signaling response under conditions of insulin resistance. PMID: 23875673
    30. Report effect of antidiabetic agents on endothelin receptor subtype(s) regulation/binding in type 1 diabetic rat hearts. PMID: 24144054
    31. The enhanced ETBR-mediated microvascular relaxation may contribute to the decreased vasoconstriction and vascular resistance during pregnancy. PMID: 23646960
    32. C-terminus of ETA/ETB receptors regulate endothelin-1 signal transmission. PMID: 23436727
    33. ET-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and nitric oxide production PMID: 23370722
    34. The results suggest that the ET(A)/ET(B) receptors play an important role in cerebral vasospasm after subarachnoid hemorrhage PMID: 23351051
    35. In rat trigeminal ganglion neurons, ETB activation leads to Ca2+ mobilization, a special feature in the trigeminal system. ETB-mediated Ca2+ responses occurred most frequently in neurons that were capsaicin-insensitive. PMID: 23396520
    36. Expression and contractile functions of ET(B) and 5-HT(1B) receptors were strongly upregulated and slightly downregulated, respectively, 24 h after experimental stroke. PMID: 22585122
    37. Endothelin-1 acts in an intracrine fashion on endolysosomal ET(B) to induce nitric oxide formation, thus modulating endothelial function PMID: 23086942
    38. Data indicate that mmLDL upregulates the endothelin type B (ET(B)) receptors in coronary artery, mainly via activation of the ERK1/2 MAPK and the downstream transcriptional factor NF-kappaB. PMID: 22198514
    39. The Ednrb null rats showed a low white blood cell count, significant size reduction and abnormal microarchitecture of spleen. PMID: 22975636
    40. Elevated intraocular pressure mediated increase in ET(B) receptor expression and its activation may contribute to a decrease in RGC survival as seen in glaucoma. PMID: 22916224
    41. Coronary arteries rapidly upregulate vasocontractile ETB receptors during organ culture via transcriptional mechanisms and MEK-ERK1/2 signalling. This model may mimic the mechanisms seen in ischemic conditions PMID: 22391414
    42. Our results demonstrated that ETA-R blockage is more effective in inhibiting free radical generation and improving heart antioxidant properties than ETB-R blockage under oxidative stress. PMID: 23047940
    43. Our findings demonstrate that aldosterone modulates an ET(B) cysteinyl thiol redox switch to decrease pulmonary endothelium-derived NO(.) and promote pulmonary arterial hypertension. PMID: 22787113
    44. endothelin can engage ET-B already highly concentrated in caveolae of endothelial cells to induce very rapid caveolae fission and endocytosis PMID: 22457360
    45. ET(A)-ET(B) receptor cross-talk is present in the rat basilar artery PMID: 22258095
    46. Minimally modified LDL upregulates ET(B) receptors of cerebral basilar artery via the PKC, MAPK and NF-kappaB signal pathways. PMID: 22198335
    47. Increased expression of endothelin receptor B in neurons and glia could be related to a more generalized activation of survival mechanisms involving elements of the neurovascular unit. PMID: 21801590
    48. ET(B) receptor activation in supraoptic nucleus astrocytes induces the mobilisation of [Ca(2+) ](i) , likely resulting in the activation of glutamate and nitric oxide signalling pathways. PMID: 22007724
    49. Data found that the null mutation of the Ednrb gene, thought indispensable for enteric neuron development, is insufficient to result in HSCR disease when bred onto a different genetic background in rats carrying Ednrb(sl) mutations. PMID: 21915282
    50. ET-1 acts as an anti-apoptotic factor on olfactory sensory neurons, directly through ETB and indirectly by limiting non neuronal cells death through ETA. PMID: 21035524

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
  • 组织特异性：
    Widely distributed in cell types of a variety of tissues.
  • 数据库链接：

    KEGG: rno:50672

    STRING: 10116.ENSRNOP00000014747

    UniGene: Rn.11412