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  4. Recombinant Rat ERBB receptor feedback inhibitor 1 (Errfi1)

Recombinant Rat ERBB receptor feedback inhibitor 1 (Errfi1)

  • 中文名称：
    大鼠Errfi1重组蛋白
  • 货号：
    CSB-YP007804RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Errfi1重组蛋白
  • 货号：
    CSB-EP007804RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Errfi1重组蛋白
  • 货号：
    CSB-EP007804RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Errfi1重组蛋白
  • 货号：
    CSB-BP007804RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Errfi1重组蛋白
  • 货号：
    CSB-MP007804RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Errfi1; 33; Mig6ERBB receptor feedback inhibitor 1; Gene 33 polypeptide; Mitogen-inducible gene 6 protein homolog; MIG-6; Receptor-associated late transducer; RALT
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-459
  • 氨基酸序列
    STAGVAAQD IRVPLKTGFL HNGQALGNMK TCWGSRNEFE KNFLNIDPIT MAYNLNSPAP EHLTTLGCAS PSAPGSGHFF AERGPSPKSS LPPLVIPPSE SSGQREEDQV LCGFKKLSVN GVCASTPPLT PIQSCSSPFP CAAPCDRSSR PLPPLPISED PSLDEADCEV EFLTSADTDF LLEDCVPSDF KYDVPGRRSF RGCGQINYAY FDSPTVSVAD LSCASDQNRV VPDPNPPPPQ SHRRLRRSHS GPAGSFNKPA IRISSCTHRA SPSSDEDKPE IPPRVPIPPR PAKPDYRRWS AEVTSNTYSD EDRPPKVPPR EPLSRSNSRT PSPKSLPSYL NGVMPPTQSF APDPKYVSSK ALQRQSSEGS AKAPCILPII ENGKKVSSTH YYLLPERPPY LDKYEKYFRE AEEANPSTQI QPLPAACGMV SATDKLASRM KMDVGGHGKR KHLSYVVSP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.
  • 基因功能参考文献：
    1. Mig6 functions as a molecular brake for beta-cell proliferation during glucocorticoid treatment in beta-cells, and thus, Mig6 may be a novel target for preventing glucocorticoid-induced impairments in functional beta-cell mass. PMID: 23384834
    2. RALT drives endocytosis and degradation of kinase-suppressed EGFR molecules PMID: 20421427
    3. Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation PMID: 15556944
    4. The abundance of Errfi1 in the pineal gland exhibits a >10-fold increase at night, apparently under adrenergic cyclic AMP control. PMID: 19103603
    5. MIG-6/RALT is a transcriptionally controlled inhibitor of mitogenic and transforming signals generated by the ErbB-2 oncogene. MIG-6/RALT forms a physical complex with activated ErbB-2 and co-localizes with ErbB-2 in living cells. PMID: 11003669
    6. Loss of MIG-6/RALT mRNA and protein expression occurs in ERBB2-amplified breast cancer cell lines and enhances ERBB2 oncogenic signalling. PMID: 15856022
    7. ERK activity is necessary and sufficient to induce Gene33/RALT expression. Neutralization of RALT function inhibits ErbB-2 mitogenic signalling. Hence, RAS-ERK signals control the activity of a negative feed-back loop acting on ErbB-2. PMID: 12226756
    8. Gene33/RALT inhibits mitogenic signals generated by EGFR, ErbB-4 and ErbB-2.ErbB-3 dimers, but does not affect PDGF, bFGF and IL-3 dependent cell proliferation. Hence, RALT is a pan-ErbB inhibitor. PMID: 12833145

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus.
  • 蛋白家族：
    MIG6 family
  • 数据库链接：

    KEGG: rno:313729

    STRING: 10116.ENSRNOP00000065431

    UniGene: Rn.100336