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  4. Recombinant Rat Diphosphomevalonate decarboxylase (Mvd)

Recombinant Rat Diphosphomevalonate decarboxylase (Mvd)

  • 中文名称：
    大鼠Mvd重组蛋白
  • 货号：
    CSB-YP726822RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Mvd重组蛋白
  • 货号：
    CSB-EP726822RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Mvd重组蛋白
  • 货号：
    CSB-EP726822RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Mvd重组蛋白
  • 货号：
    CSB-BP726822RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Mvd重组蛋白
  • 货号：
    CSB-MP726822RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mvd
  • Uniprot No.：
  • 别名：
    Mvd; Mpd; Diphosphomevalonate decarboxylase; EC 4.1.1.33; Mevalonate; diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-401
  • 氨基酸序列
    ASEKPQDLM VTCTAPVNIA VIKYWGKRDE ALILPINPSL SVTLHQDQLK TTTTAAISKD FTEDRIWLNG REEDVGQPRL QACLREIRRL ARKRRSTGDG DALPLSLGYK VHVASVNNFP TAAGLASSAA GYACLAYTLA RVYGVEGDLS EVARRGSGSA CRSLYGGFVE WQMGEQADGK DSIARQIAPE WHWPQLRVLI LVVSAEKKPT GSTVGMQTSV ATSTLLKFRA ESIVPERMKE MTRCIQEQDF QAFAQLTMKD SNQFHATCLD TFPPISYLND TSRRIIQLVH RFNAHHGQTK VAYTFDAGPN AVIFTLEDTV AEFVAAVRHS FPPAANGDKF LKGLQVAPVL LSDELKTSLA TEPSPGGVQY IIATQVGPGP QVLDDPHHHL LGPDGLPQRD L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
  • 基因功能参考文献：
    1. These results indicate that the upregulation of miR-214 and downregulation of MPD transcription in the liver both play a role in the development of hypocholesterolemia PMID: 26158200
    2. The 45-kDa isoform of mevalonate pyrophosphate decarboxylase has been detected in the matrix of the liver peroxisomes, whereas the 37-kDa form localizes primarily to the liver cytosol. PMID: 11767099
    3. Distribution of mevalonate pyrophosphate decarboxylase is significantly reduced in the liver as well as brain of the stroke-prone spontaneously hypertensive rat from the age of two weeks, compared to that of the normotensive Wistar Kyoto strain. PMID: 11767113
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Diphosphomevalonate decarboxylase family
  • 数据库链接：

    KEGG: rno:81726

    STRING: 10116.ENSRNOP00000018145

    UniGene: Rn.10288