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  4. Recombinant Rat Delta-type opioid receptor (Oprd1), partial

Recombinant Rat Delta-type opioid receptor (Oprd1), partial

  • 货号：
    CSB-YP016358RA1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016358RA1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016358RA1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016358RA1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016358RA1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Oprd1; Ror-a; Delta-type opioid receptor; D-OR-1; DOR-1; Opioid receptor A
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
  • 基因功能参考文献：
    1. DOR1 and DOR2 subtype selective ligands can act differentially on individual ventral tegmental area (VTA) neurons and that when both are expressed in a single neuron the postsynaptic response to one does not predict the presence or valence of the response to the other. DOR subtypes not only differentially control individual neurons, but also modulate different, partially overlapping, subpopulations of VTA neurons. PMID: 28645621
    2. Hypoxia significantly modifies the miRNA profile in the liver, while opioid receptor delta activation can modify the hypoxic modification. PMID: 29262398
    3. these results expand the known function of GRK2, identifying a non-internalizing role to maintain peripheral DOR in an analgesically incompetent state. PMID: 27568556
    4. Results from this study demonstrate the convergence of three important systems, norepinephrine, corticotropin-releasing factor, and delta opioid receptors, in the amygdala and provide insight into their functional role in modulating stress and anxiety responses. PMID: 27376372
    5. Results suggest that mu opioid receptor-induced suppression of excitatory propagation in the insular cortex is an underlying mechanism of the powerful analgesic effects of mu opioid receptor agonists. In contrast, delta opioid receptors may play a minor role in suppressing acute pain. PMID: 27246300
    6. After IR, the delta-opioid receptor may mediate, in part, cardioprotection against necrosis but not apoptosis. PMID: 25639363
    7. delta-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice PMID: 24758591
    8. Specific agonism of DOR-1 induces place preference in ethanol-drinking animals. PMID: 24033469
    9. Our data demonstrate that mu-delta heteromer signaling does not desensitize and is regulated differently from mu- and delta-receptor signaling following prolonged morphine treatment. PMID: 24976397
    10. Data indicate that delta-opioid receptor (DOR)activation rescues TrkB signaling by reversing ischemia/reperfusion induced decrease in the full-length TrkB receptor and reduces brain injury in ischemia/reperfusion. PMID: 23844255
    11. Activation of delta and mu opioid receptors relieves pain induced both mechanically and by heat. PMID: 23843537
    12. The delta2 opioid receptor plays a key role in preventing cardiomyocytes from apoptosis during hypoxia/reoxygenation injury. PMID: 22592774
    13. CB(1)R-DOR heteromers have a role in altered cortical function of DOR during neuropathic pain PMID: 23272051
    14. analysis of delta-opioid receptor activation and microRNA expression of the rat cortex in hypoxia PMID: 23272113
    15. In the corpus striatum, signaling capabilities of delta opioid receptor are linked to changes in CB1 receptor or dopamine D2 receptor. PMID: 23286559
    16. Unlike delta-opioid receptors, activated mu- opioid type are partly capable of turning pulmonary C-fiber-mediated, rapid-shallow breathing rats into an appneic state. PMID: 22796630
    17. delta-opioid transmission modulates the expression of L-DOPA (dopamine)-induced dyskinesias in rodents; the delta-opioid receptors involved in this effect are located on terminals of corticostriatal neurons. PMID: 22575599
    18. the expression of delta opioid receptor in the rat brain is upregulated by hypoxia-inducible factor-1alpha following exposure to 7-day hypoxic preconditioning PMID: 22200548
    19. data suggest that DOR-KOR heteromers exist in rat primary sensory neurons and that KOR antagonists can act as modulators of DOR agonist responses most likely through allosteric interactions between the protomers of the DOR-KOR heteromer PMID: 22072818
    20. These data support the role of the delta-opioid receptor in the regulation of mood, and suggest that AZD2327, a highly selective delta-opioid receptor agonist, may possess unique antidepressant and anxiolytic activities. PMID: 21444630
    21. JWA is required for maintaining the stability of DOR via the ubiquitin-proteasome pathway in chronic morphine dependence. PMID: 21600884
    22. Direct control of opioids via delta-receptors(DOR) occurs on GnRH neurons and validates use of GT1 cells to further investigate nature of DOR present on GnRH neurons. (Delta receptor, GnRH) PMID: 16405927
    23. Data suggest that the cardiac opioid system and delta opioid receptor regulate neonatal and adult heart function through the autonomic nervous system. PMID: 21280046
    24. Data suggest that multiple reproductive experiences influence both gene activity and kappa, mu, and delta opioid receptor expression in the periaqueductal gray. PMID: 20574683
    25. Provide direct evidence that activation of DOR in the central amygdala reduces anxiety-like behavior and suggest that DOR in this area are important for regulating anxious states. PMID: 20730419
    26. These findings demonstrate that delta-opioid receptor activation selectively inhibits inputs activated by icilin, whereas mu-opioid receptor activation has a more widespread effect on synaptic inputs to neurons in the superficial dorsal horn. PMID: 20977770
    27. Coexistence of delta-opioid receptors and mu-opioid receptors in small dorsal root ganglia neurons is a basis for direct interaction of opioid receptors in modulation of nociceptive afferent transmission and opioid analgesia. PMID: 20615975
    28. p300 is dynamically associated with the dor gene. PMID: 20399742
    29. Electroacupuncture can up-regulate delta-opioid receptor and protect the brain from ischemia-reperfusion injury. PMID: 18559244
    30. DOR activation increased the activity of major antioxidant enzymes, glutathione peroxidase and superoxide dismutase, and decreased malondialdehyde and nitric oxide levels in the cortex exposed to cerebral ischemia/reperfusion. PMID: 19709398
    31. interaction between micro- and delta-opioid receptors causes a change in the functional response to micro ligands, possibly by the formation of a micro/delta heterodimer with distinct functional properties. PMID: 12488540
    32. Presence of mu, delta, and kappa opioid receptors in inner ear. May have both presynaptic and postsynaptic roles. PMID: 12855366
    33. Distinct distribution patterns suggest a specific role for delta opioid receptors in the developing caudate-putamen nucleus, compared to mu-opioid receptors. PMID: 14608598
    34. The predominant sites of expression of DOR genes in the rat hippocampal formation are GABAergic neurons, a finding that supports the view that opioids facilitate excitation of principal cells indirectly. PMID: 14689476
    35. both negative and positive functional interaction between delta, mu and kappa opioid receptors regulate the influence of MET on H(2)O(2) and NO production in rat peritoneal macrophages PMID: 15467355
    36. DOR-immunoreactive neurons may be associated with nociceptive and/or chemoreceptive function in the cranial sensory ganglia PMID: 15862537
    37. the distal carboxyl tails have roles in the action of mu and delta opioid receptor hetero-oligomers PMID: 16159882
    38. Delta-opioid receptor is involved in neuroprotection induced by rapid hypoxia preconditioning in cortical neurons. PMID: 16514101
    39. These data demonstrate the effectiveness of a spinally administered deltaOR agonist following peripheral nerve injury and indicate deltaORs are potential therapeutic targets in the treatment of NP pain. PMID: 17175187
    40. glial activation contributes to a state of opioid analgesic tolerance, & suggest that neuro-glial communication is likely responsible in part for the altered functional competence in delta opioid receptor-mediated effects following morphine treatment. PMID: 17352824
    41. The present findings demonstrate a redistribution of DOR in the NAcb following cocaine withdrawal and provide anatomical evidence supporting D1R regulation of DOR function in a subset of NAcb neurons. PMID: 18417105
    42. Activation of spinal cord delta opioid receptors, located on dynorphin terminals, inhibits dynorphin release. PMID: 18541716
    43. Thus, data show changes in the DOR mRNA expression during the development of chronic inflammatory pain, in thalamic and brainstem nuclei implicated in pain processing mechanisms. PMID: 18572383
    44. The results of these studies suggest that activation of the presynaptic delta-opioid receptor by enkephalin prevents the increase in neuronal Na(V)1.7 in DRG through inhibition of PKC and p38. PMID: 18579738
    45. deactivation of inhibitory mechanisms by opioid receptor activation in the lateral parabrachial nucleus releases sodium intake if excitatory signals were activated (sodium depletion) or not PMID: 18602454
    46. Here we show that DOR activity in the ventral tegmental area (VTA) robustly decreases ethanol consumption in rats and that these effects depend on baseline ethanol consumption. PMID: 19036960
    47. data suggest that delta-opioid receptor activation plays an important role in neuroprotection against mitochondrial respiratory chain injury PMID: 19056363
    48. extensive colocalization between alpha(2A)-adrenergic and delta-opioid receptors (DOP) on substance P (SP)-immunoreactive (-ir) varicosities in the superficial dorsal horn of the spinal cord and in peripheral nerve terminals in the skin were observed PMID: 19180644
    49. Together, these findings establish distinct roles for MOR and DOR in cocaine relapse and suggest that NAc MOR could be an important therapeutic target to neutralize the effects of endogenous beta-endorphin release on cocaine relapse. PMID: 19279569
    50. Inhibition of Cdk5 activity or overexpression of a delta-opioid receptor mutant lacking the Cdk5 phosphorylation site, results in low levels of delta-opioid receptor expression. PMID: 19295160

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Detected in brain, brain stem and brain cortex.
  • 数据库链接：

    KEGG: rno:24613

    STRING: 10116.ENSRNOP00000014084

    UniGene: Rn.10310