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  4. Recombinant Rat Carboxypeptidase B2 (Cpb2)

Recombinant Rat Carboxypeptidase B2 (Cpb2)

  • 中文名称：
    Recombinant Rat Carboxypeptidase B2(Cpb2),Yeast
  • 货号：
    CSB-YP872122RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Carboxypeptidase B2(Cpb2),Yeast
  • 货号：
    CSB-EP872122RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Carboxypeptidase B2(Cpb2),Yeast
  • 货号：
    CSB-EP872122RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Carboxypeptidase B2(Cpb2),Yeast
  • 货号：
    CSB-BP872122RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Carboxypeptidase B2(Cpb2),Yeast
  • 货号：
    CSB-MP872122RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cpb2Carboxypeptidase B2; EC 3.4.17.20; Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor; TAFI
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    114-422
  • 氨基酸序列
    ASSSYYE QYHSLNEIYS WIEVITEQHP DMLQKIYIGS SYEKYPLYVL KVSGKEHRVK NAIWIDCGIH AREWISPAFC LWFIGYVTQF HGKENTYTRL LRHVDFYIMP VMNVDGYDYT WKKNRMWRKN RSVHMNNRCV GTDLNRNFAS KHWCEKGASS FSCSETYCGL YPESEPEVKA VADFLRRNIN HIKAYISMHS YSQQILFPYS YNRSKSKDHE ELSLVASEAV RAIESINKNT RYTHGSGSES LYLAPGGSDD WIYDLGIKYS FTIELRDTGR YGFLLPERFI KPTCAEALAA VSKIAWHVIR NS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
  • 基因功能参考文献：
    1. Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension. PMID: 28289017
    2. Thrombin-activatable fibrinolysis inhibitor is activated in an instant blood-mediated inflammatory reaction after intraportal islet transplant. PMID: 24188431
    3. Carboxypeptidase B2 and complement C3 were more abundant in the cerebrospinal fluid of experimental autoimmune encephalomyelitis rats that did not respond to minocyline treatment. PMID: 22768796
    4. Arterial, platelet-rich thrombi in vivo are degraded by naturally generated plasminogen activators. TAFI may play a significant role in the control of these mechanisms. PMID: 11848438
    5. an increase in circulating TAFIa impairs endogenous clot lysis in a rat model of fibrin deposition PMID: 12958609
    6. the region comprising alpha-helix 9 and beta-sheet 11 contributes to both human and rat TAFIa stability PMID: 18513211
    7. TAFI regulates plasmin activity through its enzymatic activity whereby it reduces the plasminogen-binding capacity of the hepatocytes; gene expression is down-regulated in hepatocyte proliferation for producing a fibrinolytic environment for cell growth PMID: 19386599

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M14 family
  • 组织特异性：
    Plasma; synthesized in the liver.
  • 数据库链接：

    KEGG: rno:113936

    STRING: 10116.ENSRNOP00000014909

    UniGene: Rn.12572