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  4. Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2 (Camkk2)

Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2 (Camkk2)

  • 中文名称：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2(Camkk2),Yeast
  • 货号：
    CSB-YP004473RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2(Camkk2),Yeast
  • 货号：
    CSB-EP004473RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2(Camkk2),Yeast
  • 货号：
    CSB-EP004473RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2(Camkk2),Yeast
  • 货号：
    CSB-BP004473RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase kinase 2(Camkk2),Yeast
  • 货号：
    CSB-MP004473RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Camkk2Calcium/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; EC 2.7.11.17; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-587
  • 氨基酸序列
    SSCVSSQPT SDRAAPQDEL GSGGVSRESQ KPCEALRGLS SLSIHLGMES FIVVTECEPG RGVDLSLARD QPLEADGQEL PLDASEPESR SLLSGGKMSL QERSQGGPAS SSSLDMNGRC ICPSLSYSPA SSPQSSPRMP RRPTVESHHV SITGLQDCVQ LNQYTLKDEI GKGSYGVVKL AYNENDNTYY AMKVLSKKKL IRQAGFPRRP PPRGTRPAPG GCIQPRGPIE QVYQEIAILK KLDHPNVVKL VEVLDDPNED HLYMVFELVN QGPVMEVPTL KPLSEDQARF YFQDLIKGIE YLHYQKIIHR DIKPSNLLVG EDGHIKIADF GVSNEFKGSD ALLSNTVGTP AFMAPESLSE TRKIFSGKAL DVWAMGVTLY CFVFGQCPFM DERIMCLHSK IKSQALEFPD QPDIAEDLKD LITRMLDKNP ESRIVVPEIK LHPWVTRHGA EPLPSEDENC TLVEVTEEEV ENSVKHIPSL ATVILVKTMI RKRSFGNPFE GSRREERSLS APGNLLTKKP TREWEPLSEP KEARQRRQPP GPRASPCGGG GSALVKGGPC VESCGAPAPG SPPRTPPQQP EEAMEPE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D. Seems to be involved in hippocampal activation of CREB1. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching.
  • 基因功能参考文献：
    1. phosphorylation of CaMKKbeta regulates its half-life. PMID: 21669867
    2. in contrast to the alpha isoform, CaMKKbeta exhibited increased autonomous activity, which was caused, at least in part, by autophosphorylation at Thr(482), resulting in partial disruption of the autoinhibitory mechanism PMID: 21859090
    3. This study demonistrated that isoform-specific function for CaMKIIbeta that regulates ubiquitin signaling at the centrosome and thereby orchestrates dendrite patterning, with important implications for neuronal connectivity in the brain. PMID: 21725312
    4. Overexpression of CaMKKbeta in mammalian cells increases AMPK activity, whereas pharmacological inhibition of CaMKK, or downregulation of CaMKKbeta using RNA interference, almost completely abolishes AMPK activation PMID: 16054096
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, neuron projection.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 组织特异性：
    Mainly expressed in brain, but detected in all tissues tested (at protein level). In the brain, isoform 1 may be predominant. with high levels in the cerebellum and hippocampus, although isoform 3 is detectable. Isoform 3 is also expressed in lung.
  • 数据库链接：

    KEGG: rno:83506

    STRING: 10116.ENSRNOP00000001774

    UniGene: Rn.229208