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  4. Recombinant Rat CREB-regulated transcription coactivator 2 (Crtc2)

Recombinant Rat CREB-regulated transcription coactivator 2 (Crtc2)

  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 2(Crtc2),Yeast
  • 货号：
    CSB-YP667310RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 2(Crtc2),Yeast
  • 货号：
    CSB-EP667310RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 2(Crtc2),Yeast
  • 货号：
    CSB-EP667310RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 2(Crtc2),Yeast
  • 货号：
    CSB-BP667310RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 2(Crtc2),Yeast
  • 货号：
    CSB-MP667310RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Crtc2; Torc2CREB-regulated transcription coactivator 2; Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-691
  • 氨基酸序列
    ATSGANGPG SATASASNPR KFSEKIALQK QRQAEETAAF EEVMMDIGST RLQAQKLRLA YTRSSHYGGS LPNVNQIGCG LAEFQSPLHS PLDSSRSTRH HGLVERVQRD PRRMVSPLRR YPRHIDSSPY SPAYLSPPPE SGWRRMMPWG NLPAEKGQLF RLPSALNRTS SDSALHTSVM NPNPQDTYPG PTPPSVLPSR RGGFLDGEMD AKVPAIEENL VDDKHLLKPW DAKKLSSSSS RPRSCEVPGI NIFPSPDQPA NVPVLPPAMS TGGSLPDLTN LHFPPPLPTP LDPEETVYPS LSGGNSTTNL THTMTHLGIS GGLGLGPSYD VPGLHSPLSH PSLQSSLSNP NLQASLSSPQ PQLQGSHSHP SLPASSLAHH ALPTTSLGHP SLSAPALSSS SSSSSTSSPV LSAPPYPAST PGASPRHRRV PLSPLSLPAG PADARRSQQQ LPKQFSPTMS PTLSSITQGV PLDTSKLPTD QRLPPYPYSP PSLVIPSHPP TPKSLQQLPS QACLVQPSGG QPPGRQPHYG TLYPPGSSGH GQQPYHRPIN DFSLGNLEQF NMESPSTSLV LDPPAFSEGP GFLGSEGSVS GPQDSHVLNH QNLTHCSRHG SGPNIILTGD SSPGFSKEIA AALAGVPGFE VSASGLELGL GLEDELRMEP LGLEGLTMLS DPCALLPDPA VEDSFRSDRL Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.
  • 基因功能参考文献：
    1. Berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway. PMID: 26167077
    2. These data suggest mTORC2 phosphorylation of Akt is a key mediator of H2S-induced cardioprotection in I/R. PMID: 24949720
    3. Suggest that CRTC2 participates in CREB-dependent photic entrainment of suprachiasmatic nucleus function. PMID: 25080490
    4. CRTC2 inhibition resulted in reduced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert amino acids to gluconeogenic intermediates PMID: 23595987
    5. CRTC2 and calcineurin are critical signaling mediators in FSH and TGFbeta1-stimulated steroidogenesis in ovarian granulosa cells. PMID: 21826657
    6. The differential distribution patterns are consistent with complex roles for TORC1, -2, and -3 isoforms in diverse brain structures. PMID: 21679259
    7. Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling PMID: 21784900
    8. the temporal relationship between nuclear accumulation of TORC2 and the increase in transcription of steroidogenic proteins, implicates TORC2 in the physiological regulation of steroidogenesis in the adrenal cortex. PMID: 21083631
    9. Gastric inhibitory polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by CREB and TORC2. PMID: 18086876
    10. We propose that adiponectin and thiazolidinedione promote the modulation of AMPK-dependent CRTC2 activity to influence hepatic gluconeogenesis. PMID: 19381067
    11. data identify CRTC2 as a new hypothalamic AMP-activated protein kinase target and highlight a role for CRTC2 in the mechanisms linking hypothalamic glucose sensing with CRE gene regulation. PMID: 19713961

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TORC family
  • 数据库链接：

    KEGG: rno:310615

    STRING: 10116.ENSRNOP00000021700

    UniGene: Rn.13599