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  4. Recombinant Rat CDK5 regulatory subunit-associated protein 3 (Cdk5rap3)

Recombinant Rat CDK5 regulatory subunit-associated protein 3 (Cdk5rap3)

  • 中文名称：
    Recombinant Rat CDK5 regulatory subunit-associated protein 3(Cdk5rap3),Yeast
  • 货号：
    CSB-YP872881RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat CDK5 regulatory subunit-associated protein 3(Cdk5rap3),Yeast
  • 货号：
    CSB-EP872881RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat CDK5 regulatory subunit-associated protein 3(Cdk5rap3),Yeast
  • 货号：
    CSB-EP872881RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat CDK5 regulatory subunit-associated protein 3(Cdk5rap3),Yeast
  • 货号：
    CSB-BP872881RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat CDK5 regulatory subunit-associated protein 3(Cdk5rap3),Yeast
  • 货号：
    CSB-MP872881RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdk5rap3
  • Uniprot No.：
  • 别名：
    Cdk5rap3CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-504
  • 氨基酸序列
    MQDHQHVPID IQTSKLLDWL VDRRHCNLKW QSLVLTIREK INTAIQDMPE SQEIAQLLSG SYIHYFHCLR IVDLLKGTEA STKNIFGRYS SQRMKDWQEI ISLYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QDYSRKEEEG QAGAAEMREQ FYHSCKQYGI TGDNVRRELL ALVKDLPSQL AEIGAGAQSL GEAIDLYQAC VEFVCDSPTE QVLPMLRYVQ PKGNSTVYEW RTGTEPSVVE RPQLEDPPEQ VQEDEIDWGD FGLEAVSDSG NIISAETPGI DWGISLESES KDAGADKIDW GDNAVASEIT VLETGTEAPE GVARGSDALT LLEYPETRNQ FIDELMELEI FLSQRAVEMS EEADILSVSQ FQLAPAILQG QTKEKMLSLV STLQHLIGQL TSLDLQHLFM ILASPRYVDR VTELLQQKLK QSQLLALKKD LMVEKQQEAL QEQAALEPKL DLLLEKTREL QKLIEADISK RYNGRPVNLM GTSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1. Required for liver development.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CDK5RAP3 family
  • 组织特异性：
    Expressed in vascular endothelium. Up-regulated in failing heart. Highly expressed in the ventricular section in subacute and chronic ischemic heart failure.
  • 数据库链接：

    STRING: 10116.ENSRNOP00000065240

    UniGene: Rn.3727