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  4. Recombinant Rat CCAAT/enhancer-binding protein beta (Cebpb)

Recombinant Rat CCAAT/enhancer-binding protein beta (Cebpb)

  • 中文名称：
    Recombinant Rat CCAAT/enhancer-binding protein beta(Cebpb),Yeast
  • 货号：
    CSB-YP005181RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat CCAAT/enhancer-binding protein beta(Cebpb),Yeast
  • 货号：
    CSB-EP005181RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat CCAAT/enhancer-binding protein beta(Cebpb),Yeast
  • 货号：
    CSB-EP005181RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat CCAAT/enhancer-binding protein beta(Cebpb),Yeast
  • 货号：
    CSB-BP005181RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat CCAAT/enhancer-binding protein beta(Cebpb),Yeast
  • 货号：
    CSB-MP005181RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cebpb; Crp2; Nf-il6; Sfb; CCAAT/enhancer-binding protein beta; C/EBP beta; C/EBP-related protein 2; Interleukin-6-dependent-binding protein; IL-6DBP; Liver-enriched inhibitory protein; LIP; Liver-enriched transcriptional activator; LAP; Silencer factor B; SF-B
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-297
  • 氨基酸序列
    MHRLLAWDAA CLPPPPAAFR PMEVANFYYE PDCLAYGAKA ARAAPRAPAA EPAIGEHERA IDFSPYLEPL APAAADFAAP APAHHDFLSD LFADDYGAKP SKKPSDYGYV SLGRAGAKAA PPACFPPPPP AALKAEPGFE PADCKRADDA PAMAAGFPFA LRAYLGYQAT PSGSSGSLST SSSSSPPGTP SPADAKAAPA ACFAGPPAAP AKAKAKKAVD KLSDEYKMRR ERNNIAVRKS RDKAKMRNLE TQHKVLELTA ENERLQKKVE QLSRELSTLR NLFKQLPEPL LASAGHC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-TEssential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.; Acts as a dominant negative through heterodimerization with isoform 2. Promotes osteoblast differentiation and osteoclastogenesis.
  • 基因功能参考文献：
    1. C/EBPbeta plays a role in cardiac fibroblast differentiation in a rat model of cardiac fibrosis induced by autoimmune myocarditis. PMID: 30305575
    2. The present study indicates a requirement for C/EBPbeta in the insulin-mediated induction of SREBP-1c mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors. PMID: 27382175
    3. C/EBP beta acts as a potent pro-inflammatory mediator by inducing the TNF-alpha gene at the transcription and protein levels via the ERK1/2 and p38 pathways in nucleus pulposus. PMID: 26505752
    4. Lipopolysaccharide elicits depressive-like behaviour in both sexes, inflammation may shape phenotype via hypothalamus in a sex-dependant manner, C/EBPbeta variants and glucocorticoid receptor signaling may be inflammatory mediators of these processes PMID: 26024764
    5. C/EBPbeta was the main regulator of P2X7 receptor expression in response to a glucose challenge. C/EBPalpha and the C/EBPbeta-LIP isoform blocked the C/EBPbeta-dependent regulation of P2X7 receptor transcription. PMID: 25403356
    6. results revealed a robust anti-hypertrophic and anti-remodeling effect of ALA, which is mediated by inhibition of C/EBPbeta activation. PMID: 25450863
    7. Results show that C/EBP-beta is activated in the dorsal root ganglion neurons by a TNF-alpha-dependent manner and might be involved in the activation of primary afferent neurons after nerve injury PMID: 25173154
    8. C/EBPbeta bound to 5'upstream sequences of the Tmub1 gene to enhance the promoter activity. PMID: 25109894
    9. CEBPB knockdown protected cardiomyocytes from hypertrophy, which may be attributed to inhibition of RelA-dependent transcriptional activity. PMID: 24704266
    10. Data demonstrate, that in neurons, C/EBP beta isoforms are differently modulated in apoptosis PMID: 24438488
    11. NF-IL6 can be used as a broad activation marker in the brain PMID: 24279606
    12. data indicate that the mechanism of IL-6 and TGF-beta1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9 up-regulated p300 and p300-mediated C/EBPbeta acetylation PMID: 24344329
    13. ER stress-related calpain downregulates the PPAR-gamma/HO-1 pathway via C/EBP-beta and leads to aggravated death of activated microglia via IL-13, thereby preventing cerebral inflammation and neuronal injury. PMID: 23881867
    14. Our results indicate that exendin-4 inhibits the activation of SREBP1c and C/EBPbeta, which, in turn, may reduce glucolipotoxicity-induced ER stress and beta-cell apoptosis. PMID: 23257266
    15. Site-directed mutagenesis of the proximal Runx1 and C/EBPbeta consensus elements in the P2X3 promoter decrease Runx1- and C/EBPbeta-mediated transcriptional activity. PMID: 21678417
    16. Epimorphin regulates bile duct formation of WB-F344 cells through effects on RhoA and C/EBPbeta, implicating a dual aspect of this morphoregulator in bile duct epithelial morphogenesis. PMID: 21935930
    17. C/EBPbeta stimulates Pdk4 expression and participates in the T(3) induction of the Cpt1a and Pdk4 genes. PMID: 21586575
    18. Increase of plasma glucose is related to the lower expression of C/EBPbeta and C/EBPdelta proteins in the lung of STZ-diabetic rats. PMID: 21249617
    19. The induction of C/EBPbeta expression in female offspring skeletal muscle by maternal protein restriction during pregnancy may indicate C/EBPbeta involvement in signaling response in energy metabolism to a low maternal protein diet. PMID: 20930553
    20. Endoplasmic reticulum stress triggers suppression of AMPK while increasing C/EBPbeta and pCREB expression which activates PEPCK gene transcription. PMID: 20797423
    21. These data indicate that C/EBPbeta represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/EBPbeta is a central signal in physiologic hypertrophy and proliferation. PMID: 21183071
    22. CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein PMID: 20452968
    23. activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in haptoglobin gene upregulation as a transcriptional coactivator. PMID: 20155810
    24. Results identify four novel C/EBPbeta-activating modifications, including RSK-mediated phosphorylation of a bifunctional residue in the leucine zipper that regulates DNA binding and homodimerization and thereby promotes cell cycle arrest. PMID: 20351173
    25. Endoplasmic reticulum stress blunts cytokine-triggered activation of NF-kappaB, in part through PERK- and IRE1-mediated preferential induction of C/EBPbeta. PMID: 19875812
    26. C/EBPbeta moieties were anchored to the nuclear matrix through hydrophobic protein-protein interactions with the lamins PMID: 12095231
    27. CEBPB and CEBPD regulate PI3K inflammatory gene expression PMID: 12145301
    28. the C/EBP site and the enhancer binding proteins beta and gamma are involved in rat hepatic Class I ADH gene expression in vivo by ethanol PMID: 12213809
    29. CCAAT/enhancer-binding protein beta expression in osteoblasts is regulated by Fos-related antigen 2-controlled protein kinase A PMID: 15299028
    30. Stimulation of the expression of C/EBP beta isoform liver-enriched activating protein (LAP) is associated with IL-1 beta-inhibited alpha-smooth muscle actin gene expression in rat lung myofibroblasts. PMID: 15383601
    31. C/EBPbeta has a role in the cross talk between PTH and 1,25(OH)(2)D(3) that involves the regulation of VDR transcription PMID: 15601867
    32. glucocorticoids increase C/EBPbeta and delta activity and expression through a direct effect in skeletal muscle PMID: 15669083
    33. C/EBPbeta appears to be a survival factor in hepatocytes under stressful conditions PMID: 15721291
    34. CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein PMID: 15722556
    35. This factor plays important roles in the regulation of thyroid specific genes. PMID: 15785238
    36. dexamethasone antagonizes C/EBPbeta- and Nrf2-mediated GSTA2 gene induction via ligand-GR binding to the GRE, and steroid-mediated GSTA2 repression involves inactivation of C/EBPbeta and Nrf2 by SMRT recruited to steroid-GR complex PMID: 15870285
    37. Cyclic GMP-dependent protein kinase increases the DNA binding potential of C/EBPbeta by preventing the negative effects of GSK-3 phosphorylation PMID: 16055922
    38. ceramide and ERK mediate a pathway in the IL-1beta signaling cascade, which results in rapid posttranslational activation of C/EBPbeta PMID: 16106045
    39. C/EBP beta is involved in the acute-phase response regulation of transcription of the haptoglobin gene during the later phase of differentiation and in the adult. PMID: 16172914
    40. GATA-4 and CCAAT/enhancer-binding protein beta (C/EBPbeta) bind to the Star promoter and activate transcription PMID: 16682116
    41. CEBP-beta-dependent recruitment of SWI/SNF activity is required for chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene PMID: 16772287
    42. Interference was evident when a novel taste formed the second taste input. The time window for interference was found to last more than 10 h. An increase of C/EBPbeta protein expression in the gustatory cortex was found 18 h after novel taste learning. PMID: 16980548
    43. Role of this C/EBP in the mechanism of upregulation of CCL2, an inflammation-related protein, observed in the hyperinsulinaemic state, which may initiate the process of atherosclerosis. PMID: 17180354
    44. in the hippocampus both protein synthesis and C/EBPbeta expression are required for consolidation but not reconsolidation of inhibitory avoidance PMID: 17644752
    45. C/EBP-beta may enhance hematogenous metastasis and its antiapoptotic effects may promote the survival of intravascular tumor cells. PMID: 17727681
    46. Results suggest that inhibition of c/ebp beta is critical in DBP induced inhibition of steroidogenic genes. PMID: 17884934
    47. demonstrate that C/EBPbeta is not required for transcriptional activation by the AAR pathway but, when present, acts in concert with ATF3 (activating transcription factor 3) to suppress transcription during the latter stages of the response PMID: 18052938
    48. CCAAT enhancer-binding protein isoforms have distinct functions in the regulation of manganese superoxide dismutase during interleukin-1beta stimulation PMID: 18559338
    49. data suggest that the interaction between GR and C/EBP-beta contributes to elevated COX-2 gene transcription by corticosterone in cardiomyocytes PMID: 18650268
    50. Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation. PMID: 19407981

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    BZIP family, C/EBP subfamily
  • 组织特异性：
    Liver and lung.
  • 数据库链接：

    KEGG: rno:24253

    STRING: 10116.ENSRNOP00000065222

    UniGene: Rn.6479