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Recombinant Rat Aspartoacylase (Aspa)

  • 中文名称：
    Recombinant Rat Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-YP874180RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-EP874180RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-EP874180RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-BP874180RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Aspartoacylase(Aspa),Yeast
  • 货号：
    CSB-MP874180RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    AspaAspartoacylase; EC 3.5.1.15; Aminoacylase-2; ACY-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-312
  • 氨基酸序列
    MTSCVAEEPI KKIAIFGGTH GNELTGVFLV THWLKNGAEV HRAGLEVKPF ITNPRAVEKC TRYIDCDLNR VFDLENLSKE MSEDLPYEVR RAQEINHLFG PKNSDDAYDV VFDLHNTTSN MGCTLILEDS RNDFLIQMFH YIKTCMAPLP CSVYLIEHPS LKYATTRSIA KYPVGIEVGP QPHGVLRADI LDQMRRMLKH ALDFIQRFNE GKEFPPCAID VYKIMEKVDY PRNESGDVAA VIHPNLQDQD WKPLHPGDPV FVSLDGKVIP LGGDCTVYPV FVNEAAYYEK KEAFAKTTKL TLNAKSIRST LH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter.
  • 基因功能参考文献：
    1. Interaction of N-acetyl-L-aspartate accumulation due to ASPA deficiency with an unstable neuronal membrane potential caused by HCN1 deficiency was involved in tremor development. PMID: 27026062
    2. The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels. PMID: 24515258
    3. This study demonistrated that aspartoacylase expression in the rat white matter central nervous system. PMID: 21598311
    4. The develomental increase of this enzyme in oligodendrocytes parallels CNS myelination. PMID: 12524181
    5. ASPA colocalized throughout the brain with CC1, a marker for oligodendrocytes, with 92-98% of CC1-positive cells also reactive with the ASPA antibody. PMID: 15065127
    6. describe the occurrence of ASPA within nuclei of rat brain and kidney, and in cultured rodent oligodendrocytes. PMID: 16935940
    7. the N-terminal domain of aspartoacylase adopts a protein fold similar to that of zinc-dependent hydrolases related to carboxypeptidases A PMID: 17194761

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AspA/AstE family, Aspartoacylase subfamily
  • 组织特异性：
    Detected in kidney proximal tubule cells (at protein level).
  • 数据库链接：

    KEGG: rno:79251

    STRING: 10116.ENSRNOP00000050760

    UniGene: Rn.21677