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  4. Recombinant Rat Alpha-tocopherol transfer protein (Ttpa)

Recombinant Rat Alpha-tocopherol transfer protein (Ttpa)

  • 中文名称：
    大鼠Ttpa重组蛋白
  • 货号：
    CSB-YP025268RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ttpa重组蛋白
  • 货号：
    CSB-EP025268RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ttpa重组蛋白
  • 货号：
    CSB-EP025268RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ttpa重组蛋白
  • 货号：
    CSB-BP025268RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ttpa重组蛋白
  • 货号：
    CSB-MP025268RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ttpa
  • Uniprot No.：
  • 别名：
    Ttpa; Tpp1; Alpha-tocopherol transfer protein; Alpha-TTP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-278
  • 氨基酸序列
    MAEMRPGPVV GKQLNEQPDH SPLVQPGLAE LRRRAQEEGV PETPQPLTDA FLLRFLRARD FDLDLAWRLM KNYYKWRAEC PELSADLHPR SILGLLKAGY HGVLRSRDPT GSRVLIYRIS YWDPKVFTAY DVFRVSLITS ELIVQEVETQ RNGVKAIFDL EGWQISHAFQ ITPSVAKKIA AVVTDSFPLK VRGIHLINEP VIFHAVFSMI KPFLTEKIKG RIHLHGNNYK SSLLQHFPDI LPLEYGGNES SMEDICQEWT NFIMKSEDYL SSISETIQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositolphosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol.
  • 基因功能参考文献：
    1. The reduced expression of hepatic alpha-TTP and CYP4F2 genes probably leads to decreased plasma alpha-tocopherol levels and elevated alpha-tocopherol levels in the liver of streptozotocin rats. PMID: 25866300
    2. Liver X receptor regulates alpha-TTP expression through direct interaction with the alpha-TTP gene promoter, and it modulates circulating alpha-tocopherol levels. PMID: 24231105
    3. The Goto-Kakizaki (GK) rats showed an increase of the hepatic expression of the alpha-TTP gene as compared with ... controls. ... the increased hepatic alpha-TTP gene expression levels may influence plasma alpha-tocopherol levels in the diabetic animals. PMID: 23535541
    4. alpha-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport. PMID: 22147702
    5. findings show that intracellular processing of tocopherol involves a functional interaction between TTP and an ABC-type transporter. PMID: 16024914
    6. TTP transports alpha-TCP and oral administration of TTP compensates for TTP in TTP-deficient mice PMID: 16257640

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Liver.
  • 数据库链接：

    KEGG: rno:25571

    STRING: 10116.ENSRNOP00000009611

    UniGene: Rn.228762