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  4. Recombinant Rat Alpha-mannosidase 2 (Man2a1)

Recombinant Rat Alpha-mannosidase 2 (Man2a1)

  • 中文名称：
    大鼠Man2a1重组蛋白
  • 货号：
    CSB-YP013387RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Man2a1重组蛋白
  • 货号：
    CSB-EP013387RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Man2a1重组蛋白
  • 货号：
    CSB-EP013387RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Man2a1重组蛋白
  • 货号：
    CSB-BP013387RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Man2a1重组蛋白
  • 货号：
    CSB-MP013387RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Man2a1
  • Uniprot No.：
  • 别名：
    Man2a1; Mana2; Alpha-mannosidase 2; EC 3.2.1.114; Golgi alpha-mannosidase II; AMan II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-489
  • 氨基酸序列
    GFSPHIIRVE RKGQLSILQE KIDHLERLLA ENNEIISNIR DSVINLSESV EDGPRGPAGN ASQGSAHLHS AQLALQADPK DCLFASQSGN QHRDVQMLDV YDLIPFDNPD GGVWKQGFDI KYEADEWDRE PLQVFVVPHS HNDPGWLKTF NDYFRDKTQY IFNNMVLKLK EDSSRKFIWS EISYLAKWWD IIDNPKKEAV KSLLQNGQLE IVTGGWVMAD EATTHYFALI DQLIEGHQWL EKNLGVKPRS GWAIDPFGHS PTMTYLLKRA GFSHMLIQRV HYSVKKHFSL QKTLEFFWRQ NWDLGSTTDI LCHMMPFYSY DIPHTCGPDP KICCQFDFKR LPGGRYGCPW GVPPEAISPG NVQSRAQMLL DQYRKKSKLF RTKVLLAPLG DDFRFSEYTE WDLQYRNYEQ LFSYMNSQPH LKVKIQFGTL SDYFDALEKS VAAEKKGGQS VFPALSGDFF TYADRDDHYW SGYFTSRPFY KRMDRIMEF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
  • 基因功能参考文献：
    1. Data suggest that hepatocyte expression of Man2a1 (Golgi apparatus alpha-mannosidase) and Man2b1 (lysosome alpha-mannosidase) is down-regulated by biological toxin swainsonine as part of locoweed/Oxytropis kansuensis hepatotoxic damage. PMID: 25797317
    2. swainsonine from Oxytropis kansuensis could reduce the expression of MAN2A1 in brain tissues PMID: 24741992
    3. Man2a1 expression increases at night ~10-fold in the rat pineal gland, by a mechanism involving neural stimulation and norepinephrine - cyclic AMP control. PMID: 19103603
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyl hydrolase 38 family
  • 组织特异性：
    Liver.
  • 数据库链接：

    KEGG: rno:25478

    STRING: 10116.ENSRNOP00000020767

    UniGene: Rn.163804