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  4. Recombinant Rat Actin-binding Rho-activating protein (Abra)

Recombinant Rat Actin-binding Rho-activating protein (Abra)

  • 货号：
    CSB-YP809116RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP809116RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP809116RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP809116RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP809116RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Abra
  • Uniprot No.：
  • 别名：
    Abra; Ms1Actin-binding Rho-activating protein; MS1; Striated muscle activator of Rho-dependent signaling; STARS
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-375
  • 氨基酸序列
    MAPGETEREA GPAKSALQKV RRATLVINLA RGWQQWANEN STRQAQEPAG WLPGATQDLP HTPKEPGPRQ HAPKPPSPKP DGDREGRGSE EATEVSHIKR KEVTRTVVSK AYERGGDVNY LSHRYEHDGG VSEAVQPDND IDRILLSHDS PTRRRKCTNL VSELTKGWKV MEQEEPKWKS DSIDTEDSGY GGDMEERPEQ DVAQVAAARI KRPLHSQANR YSETLNCKAH RKYSQVDNLK GRWQQWADEH IQSQKLNPFS DEFDYDLAMS TRLHKGDEGY GRPKEGSKTA ERAKRAEEHI YREIMELCFV IRTMARHRRD GKIQVTFGEL FDRYVRISDK VVGILMRARK HGLVHFEGEM LWQGKDDHVV ITLLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
  • 基因功能参考文献：
    1. In rat cardiomyocytes Ms1 is exclusively found in sarcomere. A nuclear localisation site in the N-terminus is required for nuclear localisation. Ms1 has the potential to act directly in the nucleus through specific interaction with DNA in development PMID: 26656831
    2. The C-terminal half of the MS1 protein contains two independent F-actin binding domains. PMID: 22081479
    3. Results suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis. PMID: 19686740
  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines.
  • 组织特异性：
    Predominantly expressed in heart and skeletal muscle, and expressed at lower levels in adrenal gland, brain, kidney, liver, and testis.
  • 数据库链接：

    KEGG: rno:286965

    STRING: 10116.ENSRNOP00000010539

    UniGene: Rn.21198