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  4. Recombinant Rat Acid-sensing ion channel 2 (Asic2), partial

Recombinant Rat Acid-sensing ion channel 2 (Asic2), partial

  • 中文名称：
    Recombinant Rat Acid-sensing ion channel 2(Asic2),partial,Yeast
  • 货号：
    CSB-YP714041RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Acid-sensing ion channel 2(Asic2),partial,Yeast
  • 货号：
    CSB-EP714041RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Acid-sensing ion channel 2(Asic2),partial,Yeast
  • 货号：
    CSB-EP714041RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Acid-sensing ion channel 2(Asic2),partial,Yeast
  • 货号：
    CSB-BP714041RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Acid-sensing ion channel 2(Asic2),partial,Yeast
  • 货号：
    CSB-MP714041RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Asic2
  • Uniprot No.：
  • 别名：
    Asic2; Accn1; Bnac1; MdegAcid-sensing ion channel 2; ASIC2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1; neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1; BNC1; BNaC1; Mammalian degenerin homolog; MDEG
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties.
  • 基因功能参考文献：
    1. ASICs may enhance susceptibility to epileptogenesis in the piriform cortex. PMID: 25744567
    2. identified the expression and localization of different ASIC subunits in the rest and activated microglia and further elucidated the role of ASICs in microglia activation and inflammatory response PMID: 25377529
    3. identified domains of ASIC2 that are crucial to channel function and may be important for the function of other members of the ASIC family. PMID: 25583083
    4. The aim of this study was to detect the expression of ASIC2 in the nasal septum in the embryonic stage of the rat. PMID: 21566334
    5. These results uncover a new mechanism of caspase-8-mediated apoptosis induced by intracellular calcium overload that is dependent on the autophagy-related proteins LC3 and p62 upon hyperactivation of DEG/ENaC channels. PMID: 23239879
    6. Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract PMID: 22890703
    7. Suggest that interaction between ASICs and lactate in the supraoptic nucleus plays an important role in the regulatory mechanism of body fluid homeostasis. PMID: 20442265
    8. In the rodent streptozotocin model of diabetes, there are increases in expression of mrna and protein for sodium channels in the suprapotic nucleus. PMID: 12167778
    9. ASIC2b is N-terminal splice variant of ASIC2a; RT-PCR analyses confirmed the expression of ASIC2b transcripts in the circumvallate papilla and, moreover, demonstrated its expression in the foliate and fungiform papillae PMID: 12736332
    10. ASIC2b has a role in regulation of ASIC3 via the partner protein PICK-1 PMID: 14976185
    11. These data suggest that DEG/ENaC proteins are required for vessel responses to pressure and are consistent with the evolutionary conservation of mechanosensory function of DEG/ENaC proteins. PMID: 15381679
    12. Acid-sensing ion channel currents are susceptible to regulation by redox agents. (Acid-sensing ion channels) PMID: 16085050
    13. ASIC1 and -3 subunits were sensitive to Pb2+. Pb2+ inhibited ASIC currents independent of the amiloride/Ca2+ blockade. PMID: 16319075
    14. AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a, and calcineurin regulates ASIC1a and ASIC2a activity PMID: 17548344
    15. Vascular smooth muscle ASIC2 is required for normal cell migration. PMID: 17936312
    16. ASIC2-Hsc70 interactions may play a role in vascular smooth muscle cell migration and contribute to vasculogenesis and remodeling. PMID: 18310515
    17. Results indicate that the proton receptor ASIC2 is expressed in both ciliated and stereociliated cells. PMID: 18560896

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
  • 蛋白家族：
    Amiloride-sensitive sodium channel (TC 1.A.6) family, ASIC2 subfamily
  • 组织特异性：
    Expressed in sciatic nerve and dorsal root ganglion (DRG) (at protein level). Both isoforms display the same expression pattern except in DRG where isoform 2 is more abundantly expressed. Widely distributed throughout the brain. Highly expressed in the ma
  • 数据库链接：

    KEGG: rno:25364

    UniGene: Rn.37523