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  4. Recombinant Rat Acetylcholinesterase collagenic tail peptide (Colq)

Recombinant Rat Acetylcholinesterase collagenic tail peptide (Colq)

  • 中文名称：
    Recombinant Rat Acetylcholinesterase collagenic tail peptide(Colq),Yeast
  • 货号：
    CSB-YP005767RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Acetylcholinesterase collagenic tail peptide(Colq),Yeast
  • 货号：
    CSB-EP005767RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Acetylcholinesterase collagenic tail peptide(Colq),Yeast
  • 货号：
    CSB-EP005767RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Acetylcholinesterase collagenic tail peptide(Colq),Yeast
  • 货号：
    CSB-BP005767RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Acetylcholinesterase collagenic tail peptide(Colq),Yeast
  • 货号：
    CSB-MP005767RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Colq
  • Uniprot No.：
  • 别名：
    ColqAcetylcholinesterase collagenic tail peptide; AChE Q subunit; Acetylcholinesterase-associated collagen
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-458
  • 氨基酸序列
    QPTFINSV LPISAALPGL DQKKRGNHKA CCLLMPPPPP LFPPPFFRGS RSPLLSPDMK NLLELEASPS PCMQGSLGSP GPPGPQGPPG LPGKAGPKGE KGDLGRPGRK GRPGPPGVPG EPGPVGWPGP EGPRGEKGDV GMMGLPGSRG PMGSKGFPGS RGEKGSRGER GDLGPKGEKG FPGFPGMLGQ KGEMGPKGES GIAGHRGPTG RPGKRGKQGQ KGDSGIMGPP GKPGPSGQPG RQGPPGPPGP PSAGQLVMGL KGERGFPGPP GRCLCGPPAN VNNPSYGDPM YGRGSPRVPA IFVVNNQEEL EKLNTQNAIA FRRDQRSLYF KDSLGWLPIQ LTPFYPVGLH HKAAWHLCGD GVLQPGEECD DGNPDVSDGC IDCHRAYCGD GYRHRGVEDC DGSDFGYLKC ETYLPGSYGE LRCTQYCSID STPCRYFT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
  • 基因功能参考文献：
    1. Extensive neural suppression of the extrajunctional ColQ expression in regenerating fast muscles during maturation is a very slow process requiring 30-60 days. PMID: 22944068
    2. differential distribution of P-CREB in fast-and slow-twitch muscles might support the crucial role of cAMP-dependent signaling in controlling the synapse-specific expression of ColQ-1a in fast-twitch muscles PMID: 23159887
    3. AChE, BChE and PRiMA mRNA level modifications found in the absence of ColQ cannot compensate for the physiological defects observed at the ColQ-deficient neuromuscular junction. PMID: 20153305
    4. extrajunctional levels of ColQ mRNA in non-innervated regenerating fast and slow muscles PMID: 20188715
    5. Extrajunctional collagen Q expression in fast muscles is independent of muscle activation and is partly nerve-dependent. PMID: 18373559
    6. In addition to its structural role, ColQ has important regulatory functions at the synapse by controlling acetylcholine receptor clustering through its interaction with MuSK. PMID: 20053883
    7. Two heparin-binding domains with different properties that may have non-redundant functions are described; may coordinate acetylcholinesterase positioning within the the neuromuscular junction basal lamina. PMID: 12684510
    8. Acetylcholinesterase associates differently with its anchoring proteins ColQ and PRiMA PMID: 18511416

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  • 亚细胞定位：
    Cell junction, synapse.
  • 蛋白家族：
    COLQ family
  • 组织特异性：
    Expressed in skeletal muscle, heart, brain, as well as in lung, spleen, testis, but not liver. The short isoform represents about 5% of the transcripts in the soleus muscle and about 15% in the heart ventricle.
  • 数据库链接：

    KEGG: rno:29755

    UniGene: Rn.87303