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  4. Recombinant Rabies virus Glycoprotein (G), partial

Recombinant Rabies virus Glycoprotein (G), partial

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  • 中文名称：
    Recombinant Rabies virus Glycoprotein(G),partial
  • 货号：
    CSB-YP389005RIE
  • 规格：
    ￥2616
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP389005RIE could indicate that this peptide derived from Yeast-expressed Rabies virus (strain India) (RABV) G.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP389005RIE could indicate that this peptide derived from Yeast-expressed Rabies virus (strain India) (RABV) G.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    G
  • Uniprot No.：
  • 别名：
    Glycoprotein
  • 种属：
    Rabies virus (strain India) (RABV)
  • 蛋白长度：
    Partial
  • 来源：
    Yeast
  • 分子量：
    51.4kDa
  • 表达区域：
    20-459aa
  • 氨基酸序列
    KFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGFSYMELKVGYISAIKVNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYHWLRTVKTTKESLVIISPSVADLDPYDKSLHSRVFPSGKCSGITISSTYCSTNHDYTIWMPENPRLGTSCDIFTNSRGKRASKGGKTCGFVDERGLYKSLKGACKLKLCGVLGLRLMDGTWVAMQTSDETKWCPPDQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMATKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLRVGGRCHPHVNGVFFNGIILGPDGHVLIPEMQSSLLQQHMELLESSVIPLMHPLADPSTVFKDGDEAEDFVEVHLPDVHKQISGVDLGLPSWGKY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    A target DNA fragment corresponding to 20-459aa of Rabies virus (strain India) (RABV) was expressed with N-terminal 6xHis-tags in yeast. The resulting protein is the Yeast-expressed Recombinant Rabies Virus Glycoprotein (G). Its purity is greater than 90% as determined by SDS-PAGE. And it contains 440 amino acids and has a calculated molecular weight of 51.4 kDa. As the only surface protein of the rabies virion, the RABV G protein can induce the production of virus-neutralizing antibodies (VNA).

    Rabies virus G is a component constituting the envelope of the rabies virus, which is the causative agent of rabies. Rabies is an ancient zoonotic disease that causes tens of thousands of deaths around the globe annually. RABV G is a key determinant for the induction of innate immune responses and consequent pathogenesis. The binding of RABV G to neural receptors such as acetylcholine receptor or neural cell adhesion molecules (NCAM), leading to exclusive neurotropism and neuroinvasiveness of RABV.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
  • 亚细胞定位：
    Virion membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Lyssavirus glycoprotein family