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  4. Recombinant Porphyromonas gingivalis Lys-gingipain (kgp), partial

Recombinant Porphyromonas gingivalis Lys-gingipain (kgp), partial

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  • 中文名称：
    Recombinant Porphyromonas gingivalis Lys-gingipain(kgp),partial
  • 货号：
    CSB-EP464342EXZ
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP464342EXZ could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) kgp.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP464342EXZ could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) kgp.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    kgp; PGN_1728Lys-gingipain; EC 3.4.22.47; Lysine-specific cysteine proteinase Kgp) [Cleaved into: Lys-gingipain catalytic subunit; 39 kDa adhesin; 15 kDa adhesin; 44 kDa adhesin]
  • 种属：
    Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    56.6kDa
  • 表达区域：
    229-594aa
  • 氨基酸序列
    DVYTDHGDLYNTPVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLAASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNIIDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSYPKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSLTATQVKALTNKDKYFLAIGNCCVTAQFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGSYDATFLEDSYNTVNSIMWAGNLAATHAGNIGNITHIGAHYYWEAYHVLGDGSVM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：
        细胞表面半胱氨酸蛋白酶 RgpA、RgpB（Arg-gingipain）和 Kgp（Lys-gingipain）是牙龈脓胞杆菌的主要毒力因子，牙龈脓胞杆菌是导致破坏性牙周病的关键病原体。龈上蛋白酶具有蛋白酶和转肽酶的功能，利用甘氨酰甘氨酸等小肽作为接受分子。
        j9九游会登录入口首页生物大肠杆菌表达系统所表达的Porphyromonas gingivalis Lys-gingipain(kgp)表达区域为229-594aa，具有高稳定性、高纯度等特点，助您进行相关研究。
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
  • 基因功能参考文献：
    1. a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions PMID: 27354280
  • 亚细胞定位：
    [Lys-gingipain catalytic subunit]: Secreted.
  • 蛋白家族：
    Peptidase C25 family
  • 数据库链接：

    KEGG: pgn:PGN_1728

    STRING: 431947.PGN_1728