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  4. Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88)

Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88)

  • 中文名称：
    斯克罗法MYD88重组蛋白
  • 货号：
    CSB-YP015282PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斯克罗法MYD88重组蛋白
  • 货号：
    CSB-EP015282PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斯克罗法MYD88重组蛋白
  • 货号：
    CSB-EP015282PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斯克罗法MYD88重组蛋白
  • 货号：
    CSB-BP015282PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斯克罗法MYD88重组蛋白
  • 货号：
    CSB-MP015282PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    MYD88; Myeloid differentiation primary response protein MyD88
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-293
  • 氨基酸序列
    MAAGGSGAES APPTPSMSSL PLAALNVRVR HRLSLFLNVR TQVAADWTGL AEEMNFEYLE IRRLETHPDP TRSLLDDWQG RPGASVGRLL ELLAKLGRDD VLVELGPSIE EDCRKYILKQ QQEAAEKPLQ VDSVDSSIPW MSGITIRDDP LGQMPEHFDA FICYCPSDIQ FVQEMIRQLE QTNYRLKLCV SDRDVLPGTC VWSIASELIE KRCRRMVVVV SDDYLQSKEC DFQTKFALSL SPGAHQKRLI PVKYKSMKKE FPSILRFITV CDYTNPCTKS WFWTRLARAL SLP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
  • 基因功能参考文献：
    1. These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway. PMID: 26581603
    2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88. PMID: 25380861
    3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals. PMID: 17976317
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Expressed in esophagus, duodenum, jejenum, ileum, ileal Peyer patches, mesenteric lymph node, colon and spleen.
  • 数据库链接：

    KEGG: ssc:396646

    STRING: 9823.ENSSSCP00000011996

    UniGene: Ssc.23492