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  4. Recombinant Pig Insulin-like growth factor-binding protein 3 (IGFBP3)

Recombinant Pig Insulin-like growth factor-binding protein 3 (IGFBP3)

  • 中文名称：
    斯克罗法IGFBP3重组蛋白
  • 货号：
    CSB-YP011097PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斯克罗法IGFBP3重组蛋白
  • 货号：
    CSB-EP011097PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斯克罗法IGFBP3重组蛋白
  • 货号：
    CSB-EP011097PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斯克罗法IGFBP3重组蛋白
  • 货号：
    CSB-BP011097PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斯克罗法IGFBP3重组蛋白
  • 货号：
    CSB-MP011097PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IGFBP3; Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-293
  • 氨基酸序列
    GSG AAGTGPVVRC EPCDARALAQ CAPPPAAPPC AELVREPGCG CCLTCALREG QACGVYTERC GAGLRCQPPP GEPRPLQALL DGRGICANAS AAGRLRAYLL PAPPAPGNGS ESEEDRSVDS MENQALPSTH RVPDSKLHSV HTKMDVIKKG HAKDSQRYKV DYESQSTDTQ NFSSESKRET EYGPCRREME DTLNHLKFLN MLSPRGIHIP NCDKKGFYKK KQCRPSKGRK RGFCWCVDKY GQPLPGFDVK GKGDVHCYSM ESK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.
  • 基因功能参考文献：
    1. IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues. PMID: 21570979
    2. Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis PMID: 21652730
    3. Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures. PMID: 21353438
    4. cloning and sequencing; regulation of IGFBP-3 transcription by FSH suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I PMID: 14715717
    5. Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK pathways. PMID: 15718291
    6. TAF4b may thus be the TFIID component that binds to the TBP site on the IGFBP-3 promoter and is essential for FSH induction of IGFBP-3. PMID: 17888567
    7. The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds. PMID: 18487150
    8. allelic frequency of TAT in Chinese breeds was over 50%; allelic frequency of GGC was over 50% in all European breeds. TAT/TAT pigs scored higher in meat color than GGC/GGC pigs. results implied that IGFBP-3 may affect meat quality & carcass traits. PMID: 19189208

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: ssc:448812

    STRING: 9823.ENSSSCP00000017719

    UniGene: Ssc.42774