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  4. Recombinant Pig Galactoside 2-alpha-L-fucosyltransferase 1 (FUT1), partial

Recombinant Pig Galactoside 2-alpha-L-fucosyltransferase 1 (FUT1), partial

  • 中文名称：
    斯克罗法FUT1重组蛋白
  • 货号：
    CSB-YP643661PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斯克罗法FUT1重组蛋白
  • 货号：
    CSB-EP643661PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斯克罗法FUT1重组蛋白
  • 货号：
    CSB-EP643661PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斯克罗法FUT1重组蛋白
  • 货号：
    CSB-BP643661PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斯克罗法FUT1重组蛋白
  • 货号：
    CSB-MP643661PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FUT1
  • Uniprot No.：
  • 别名：
    FUT1Galactoside 2-alpha-L-fucosyltransferase 1; EC 2.4.1.344; Alpha(1,2)FT 1; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis. Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.
  • 基因功能参考文献：
    1. FUT1 expression levels and low FUT2 expression levels in the intestines of Sutai pigs affected FUT1 and FUT2 enzymes, the synthesis of type 2 H and type 1 H antigens, and E. coli F18 adhesion. Moreover, low FUT2 expression levels conferred resistance to E. coli F18. PMID: 26985939
    2. Polymorphism of FUT1 and MUC4 associated with resistance to colibacteriosis was determined. PMID: 25318177
    3. The 5'-flanking region of the FUT1 gene (-1150 to +50 bp) exhibited promoter activity and the -1150-bp to -849-bp region showed negative regulation of the gene. PMID: 24336113
    4. Studied the beneficial effects of alpha (1,2)-fucosyltransferase (FUT1) M307 (A) on piglet survival on commercial farms. Piglet survival for individuals with the AA genotype was almost two-fold greater than for GG individuals. PMID: 23777352
    5. The results indicated that Sutai pigs with the AA genotype in M307 of FUT1 gene have relatively strong general disease resistance ability in piglets. PMID: 21769474
    6. The mutation at M307 in the FUT1 gene determines susceptibility of small intestinal epithelium to E. coli F18 adhesion in Sutai piglets. PMID: 21691705
    7. FUT1 mutations might play a role in pig infection by multi-pathogens, and the AA may be a favourable genotype for increasing the resistance to disease. PMID: 21695432
    8. Beneficial genotype of swine FUT1 gene governing resistance to E. coli F18 is associated with important economic traits PMID: 21869481
    9. transgenic male pigs were produced that possess an alpha alpha-1,3-galactosyltransferase knockout allele and express a randomly inserted human alpha 1,2-fucosylosyltransferase transgene PMID: 12672664
    10. Genetic variability is assocated with reproductive traits. PMID: 16130473
    11. Results showed that the genetic polymorphisms of the FUT1 locus were only detected in the 3 exotic pig breeds and indicated that FUT 1 gene and the type of breeds significantly affected total number born. PMID: 17284424
    12. Results indicated that Chinese native pig breeds lack the genetic background, FUT1 genetic polymorphisms, on the resistance to ETEC F18 bacteria. PMID: 17855256
    13. results showed that genetic polymorphisms of the FUT1 locus were only detected in western pig breeds & the Chinese Taihu, Huai & Lingao breeds; results indicated that Chinese native pig breeds lack genetic factors providing resistance to ETEC F18 bacteria PMID: 19134079

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 11 family
  • 数据库链接：

    KEGG: ssc:397138

    STRING: 9823.ENSSSCP00000003400

    UniGene: Ssc.242