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  4. Recombinant Neosartorya fumigata Probable scytalone dehydratase (arp1)

Recombinant Neosartorya fumigata Probable scytalone dehydratase (arp1)

  • 中文名称：
    Recombinant Neosartorya fumigata Probable scytalone dehydratase(arp1),Yeast
  • 货号：
    CSB-YP519399NGS
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Neosartorya fumigata Probable scytalone dehydratase(arp1),Yeast
  • 货号：
    CSB-EP519399NGS
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Neosartorya fumigata Probable scytalone dehydratase(arp1),Yeast
  • 货号：
    CSB-EP519399NGS-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Neosartorya fumigata Probable scytalone dehydratase(arp1),Yeast
  • 货号：
    CSB-BP519399NGS
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Neosartorya fumigata Probable scytalone dehydratase(arp1),Yeast
  • 货号：
    CSB-MP519399NGS
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    arp1
  • Uniprot No.：
  • 别名：
    arp1; AFUA_2G17580Scytalone dehydratase arp1; EC 4.2.1.94; Conidial pigment biosynthesis oxidase arp1
  • 种属：
    Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-168
  • 氨基酸序列
    MVEKKPNLTL EFHDYLALKK VLFDWADSYD AKDWDRLRSI IAPTLTVDYR QIGLRKWDDM PAEDYMAMIS DMDFLGDPTV KTQHLLGESW WEKISDTEVI GHHQLRAAHQ VYTDSTLQTV KLKGHGHATN EHYYRKVDGV WKFAGLKPTV RWNEYQFEDV FRAAKPSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Scytalone dehydratase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase arp2 to yield scytalone. The scytalone dehydratase arp1 then reduces scytalone to 1,3,8-THN. 1,3,8-THN is also substrate of the hydroxynaphthalene reductase arp2 to yield vermelone. Vermelone is further converted by the multicopper oxidase abr1 to 1,8-DHN. Finally the laccase abr2 transforms 1,8-DHN to DHN-melanin. DHN-melanin biosynthesis appears to be initiated in endosomes where early enzymes (abl1, ayg1, arp1 and arp2) localize, with exocytosis leading to melanin deposition on the cell surface where late enzymes (abr1 and abr2) localize. DHN-melanin is an important structural component of the outer cell wall and is required for the presence of conidial surface hydrophobins. DHN-melanin plays also a crucial role in fungal virulence, including a protective role against the host's immune defenses. DHN-melanin protects also conidia against amoeba predation.
  • 亚细胞定位：
    Endosome.
  • 蛋白家族：
    Scytalone dehydratase family
  • 数据库链接：

    KEGG: afm:AFUA_2G17580