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  4. Recombinant Mouse Zinc finger Y-chromosomal protein 2 (Zfy2)

Recombinant Mouse Zinc finger Y-chromosomal protein 2 (Zfy2)

  • 货号：
    CSB-YP324078MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP324078MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP324078MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP324078MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP324078MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zfy2
  • Uniprot No.：
  • 别名：
    Zfy2; Zfy-2Zinc finger Y-chromosomal protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-777
  • 氨基酸序列
    MDEDEIELTP EEEKSLFDGI GADAVHMDSD QISVEVQETV FLSNSDVTVH NFVPDDPDSV IIQDVIENVL IEDVHCSHIL EETDISDNVI IPEQVLDLDT AEEVSLAQFL IPDILTSSIT STSLTMPEHV LMSEAIHVSN VGHFEQVIHD SLVEREIITD PLTADISDIL VADWASEAVL DSSGMPLEQQ DDARINCEDY LMMSLDEPSK TDHEGSSEVT MNAESETDSS KLDEASPEVI KVCILKADSE VDDVGETIQA VESETDNGNE AEVTDQRTSI HVPRVNIYML ASDSQKEEED TKVIVGDEDA GGTAADTPEH EQQMDVSEIK AAFLPIAWTA AYDNNSDEIE VQNATASAML HHDESGGLDR VPKQKSKKKK RPESKQYQSA IFVAPDGQTL RVYPCMFCGK KFKTKRFLKR HIKNHPEYLA NKKYHCTECD YSTNKKISLH NHMESHKLTI KTEKTTECDD CRKNLSHAGT MHTEKGVNKT CKCKFCDYET AEQTLLNHHL LVVHRKKFPH ICGECGKGFR HPSALKKHIR VHTGEKPYEC QYCEYKSADS SNLKTHIKSK HSKEIPLKCG ICLLTFSDTK EAQQHAVLHQ ESRTHQCSHC NHKSSNSSDL KRHIISVHTK AYPHKCDMCS KGFHRPSELK KHVATHKSKK MHQCRHCDFK SPDPFLLSHH ILSAHTKNVP FKCKRCKKEF QQQCELQTHM KTHSSRKVYQ CEYCEYSTKD ASGFKRHVIS IHTKDYPHRC DFCKKGFRRP SEKNQHIMRH HKEVGLA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
  • 基因功能参考文献：
    1. Zfy2-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure. PMID: 28114340
    2. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development PMID: 26765744
    3. Zfy2 is essential for sperm formation and is essential for sperm function in assisted fertilization procedure. PMID: 26719889
    4. Zfy2 proved to be essential for the efficient operation of a 'checkpoint' during the first meiotic division that identifies and kills cells that would otherwise produce sperm with an unbalanced chromosome set. PMID: 24967676
    5. The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. PMID: 24496622
    6. Zfy2 (but not the closely related Zfy1) is sufficient to reinstate the apoptotic response to the X univalent meiotic cell. PMID: 21530259

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family, ZFX/ZFY subfamily
  • 数据库链接：

    KEGG: mmu:22768

    STRING: 10090.ENSMUSP00000111557

    UniGene: Mm.411381