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  4. Recombinant Mouse CCN family member 5 (Ccn5)

Recombinant Mouse CCN family member 5 (Ccn5)

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  • 中文名称：
    Recombinant Mouse CCN family member 5(Ccn5)
  • 货号：
    CSB-EP896674MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Ccn5
  • Uniprot No.：
  • 别名：
    Ccn5; Ctgfl; Wisp2; CCN family member 5; Connective tissue growth factor-like protein; CTGF-L; WNT1-inducible-signaling pathway protein 2; WISP-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    40.5kDa
  • 表达区域：
    24-251aa
  • 氨基酸序列
    QLCPAPCACPWTPPQCPPGVPLVLDGCGCCRVCARRLGESCDHLHVCDPSQGLVCQPGAGPSGRGAVCLFEEDDGSCEVNGRRYLDGETFKPNCRVLCRCDDGGFTCLPLCSEDVRLPSWDCPRPRRIQVPGRCCPEWVCDQAVMQPAIQPSSAQGHQLSALVTPASADGPCPNWSTAWGPCSTTCGLGIATRVSNQNRFCQLEIQRRLCLSRPCLASRSHGSWNSAF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
  • 基因功能参考文献：
    1. WISP2 is a novel secreted adipokine, most highly expressed in the subcutaneous adipose tissue and primarily in mesenchymal precursor cells. WISP2 is, to the best of our knowledge, the first identified endogenous and secreted autocrine/endocrine regulator of adipose tissue and heart/muscle cellularity and growth. PMID: 28240264
    2. Insulin-like growth factor (IGF)-1 elicited clear stimulation of WNT1 inducible signaling pathway protein 2 (CCN5/WISP2) mRNA and protein levels in cultured islets. PMID: 27863006
    3. Data suggest that CCN5, minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1 (insulin-like growth factor I); overexpression of CCN5 stimulates cell proliferation and inhibits streptozotocin-induced apoptosis. PMID: 24552398
    4. These results suggested that secreted Wisp2/CCN5 induces Akt and ERK phosphorylation via integrins, and consequently facilitates neurite formation and conferred resistance to apoptosis. PMID: 21723256
    5. CCN2 is pro-hypertrophic and -fibrotic, whereas CCN5 is anti-hypertrophic and -fibrotic. PMID: 20430035
    6. Although WISP-2 is a downstream protein of Wnt signaling, the role of WISP-2 on adipocyte differentiation may be marginal, at least in this in vitro culture model. PMID: 19135425

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    CCN family
  • 数据库链接：

    KEGG: mmu:22403

    STRING: 10090.ENSMUSP00000029188

    UniGene: Mm.13828