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  4. Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3 (Cacnb3)

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3 (Cacnb3)

  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3(Cacnb3),Yeast
  • 货号：
    CSB-YP004413MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3(Cacnb3),Yeast
  • 货号：
    CSB-EP004413MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3(Cacnb3),Yeast
  • 货号：
    CSB-EP004413MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3(Cacnb3),Yeast
  • 货号：
    CSB-BP004413MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-3(Cacnb3),Yeast
  • 货号：
    CSB-MP004413MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cacnb3; Cacnlb3; Voltage-dependent L-type calcium channel subunit beta-3; CAB3; Calcium channel voltage-dependent subunit beta 3; CCHB3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-484
  • 氨基酸序列
    MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS PQRLESIRLK QEQKARRSGN PSSLGDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT HHPAPGPGLL GPPSAIPGLQ NQQLLGERVE EHSPLERDSL MPSDEASESS RQAWTGSSQR SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHDHND RNWQRNRPWP KDSY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation.
  • 基因功能参考文献：
    1. During development Cavbeta3 protein expression in the cerebellum peaks at postnatal days 15 and 21, and has diminished drastically by day 60, and in the hippocampus increases with age throughout all subfields. PMID: 22737983
    2. In transgenic mice lacking the calcium channel beta3 subunit, there are compensatory changes of calcium channel abundance leading to adaptation of alternate calcium transport mechanisms. PMID: 19767875
    3. Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation PMID: 21040760
    4. these results indicate the importance of the beta3 subunit in determining calcium channel characteristics and catecholamine release in adrenal chromaffin cells. PMID: 20144588
    5. neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties PMID: 19755851
    6. Data show that the calcium channel beta3 subunit negatively modulates inositol triphosphate-induced calcium release. PMID: 15479643
    7. Down-regulation of Cacnb3 expression does not rescue placental hyperplasia in a model of interspecies hybrid placentas, indicaating that upregulation is a downstream event. PMID: 16822546
    8. the involvement of voltage-dependent Ca2+ channels and importance of the beta3 subunit in olfactory signal transduction PMID: 17335778
    9. Ca(V)beta(3) has only subtle effects on L-type Ca(2+) currents in ileum smooth muscle. PMID: 17580090
    10. This study showed the importance of voltage-dependent calcium channels and the key role of the beta3 subunit in memory formation, nociceptive sensory transduction, and various neurological signal transduction pathways. PMID: 17588550
    11. These results suggest a possibility that, unrelated to voltage-dependent Ca(2+) channels regulation, Ca(v)beta3 negatively regulates the NMDAR activity in the hippocampus. PMID: 18339621
    12. Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.( PMID: 18628210
    13. Deficiency in beta3 regulatory subunit of voltage-gated calcium channels resulted in a profound survival defect of CD8(+) T cells. PMID: 19838200

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calcium channel beta subunit family
  • 组织特异性：
    Detected in the inner plexiform layer in the retina (at protein level).
  • 数据库链接：

    KEGG: mmu:12297

    STRING: 10090.ENSMUSP00000003442

    UniGene: Mm.3544