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  4. Recombinant Mouse Uncharacterized protein KIAA0748 homolog

Recombinant Mouse Uncharacterized protein KIAA0748 homolog

  • 中文名称：
    小鼠Tespa1重组蛋白
  • 货号：
    CSB-YP666239MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tespa1重组蛋白
  • 货号：
    CSB-EP666239MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tespa1重组蛋白
  • 货号：
    CSB-EP666239MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tespa1重组蛋白
  • 货号：
    CSB-BP666239MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tespa1重组蛋白
  • 货号：
    CSB-MP666239MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tespa1
  • Uniprot No.：
  • 别名：
    Tespa1Protein TESPA1; Thymocyte-expressed positive selection-associated protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-458
  • 氨基酸序列
    MEASVLSPTS WEKRRAWLRQ SRNWQTQVLE EEAAAALQDA LDPEPSSLDD VFQEGNPINK IEDWLQGCGC RDTEEGLSEE SGQSNYSGYS SHGTSFEDDL SLGAEATLLS TNGNLFSRNF LQTPRLCQLL DLGSSLASSS MTGGTNKTSS SISEILDQVQ EDAEDILFSL GFGHENHKDT SRIPARFFSN PSQAKGINFQ LFLKSQVQRM EMEDPCLMLA SRFKQVQTLA VTADAFFCLY SYVSKTPVQK FTPSNMFWNF DPTDVPSIRI LAPEPEPYSP RERLRRAISK MCLYTGSRDR LSSSYNNPKK NSLDQIVWEV MDRVKGEKIQ QDPEHRQALG EESVPPIQNT NPSTSSLPCV SYPKEETQGD MCHAHALARP GPQYHINSTQ VRRQLWVLQD INEKPRSAEN ESPWERKSKA RKNLFQRVPV DKNIKSLNLP TIQQKQNQGQ ARHELTNL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes.
  • 基因功能参考文献：
    1. Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1 PMID: 28598420
    2. Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI. PMID: 25422497
    3. Tespa1 is post-translationally modified upon intracellular Ca2+ increase in thymocytes. PMID: 23541577
    4. Tespa1 is a component of the TCR signalosome and is essential for T-cell selection and maturation through regulation of TCR signaling during T-cell development. PMID: 22561606
  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane.
  • 组织特异性：
    Expressed in lymphoid tissues, with highest expression levels detected in thymus and lower levels in spleen and lymph nodes (at protein level). Detected in CD4(+) and CD8(+) T-cells, B-cells and mast cells. Not detected in monocytes/macrophages.
  • 数据库链接：

    KEGG: mmu:67596

    STRING: 10090.ENSMUSP00000047284

    UniGene: Mm.131264