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  4. Recombinant Mouse Uncharacterized protein C1orf51 homolog (Gm129)

Recombinant Mouse Uncharacterized protein C1orf51 homolog (Gm129)

  • 中文名称：
    Recombinant Mouse Uncharacterized protein C1orf51 homolog(Gm129),Yeast
  • 货号：
    CSB-YP668843MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Uncharacterized protein C1orf51 homolog(Gm129),Yeast
  • 货号：
    CSB-EP668843MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Uncharacterized protein C1orf51 homolog(Gm129),Yeast
  • 货号：
    CSB-EP668843MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Uncharacterized protein C1orf51 homolog(Gm129),Yeast
  • 货号：
    CSB-BP668843MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Uncharacterized protein C1orf51 homolog(Gm129),Yeast
  • 货号：
    CSB-MP668843MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ciart
  • Uniprot No.：
  • 别名：
    Ciart; Gm129Circadian-associated transcriptional repressor; ChIP-derived repressor of network oscillator; Chrono; Computationally highlighted repressor of the network oscillator
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-375
  • 氨基酸序列
    MDSPSSVSSY SSSSLSPSFS TSSVNSDFSF PSDNEREGKG THELRPDTVG QRGGSRPSPG PIRCRHRPRV SSNQHTAPHL EQQGSEVKRS RDGEQETSLN TQGCTTEGDL LFAQKCKELQ GFIRPLTDLL NGLKMGRFDR GLSSFQQSVA MDRIQRIVGV LQKPQMGERY LGTLLQVEGM LKTWFPHIAA QKSSSGGSRH QISKHFPSHH GDPGAASPAP LLEKMGQTQL GHLVLKPKQP WHLTGWPAMN LTWIHSTPIC NPPLSSQGSA SGHSPIGTGA SIGVILVLQK GGQPFTHSAP GTPVPPTPLS PVVPGDLKKL PGEEPRCHSL PVTLPSDWSC ILCPPVLPTT DREMTKGHPE PQMTSHPPVA PDPQP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response.
  • 基因功能参考文献：
    1. Chrono binds to the regulatory region of clock genes and its occupancy oscillates in a circadian manner. PMID: 24736997
    2. CHRONO interferes with the ability of BMAL1 to recruit CBP, a bona fide histone acetylase and key transcriptional coactivator of the circadian clock. PMID: 24737000
    3. The GM129 protein contributes to the transcriptional feedback loop by modulating CLOCK.BMAL1 activity as a transcriptional repressor. PMID: 24385426
  • 亚细胞定位：
    Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body.
  • 数据库链接：

    KEGG: mmu:229599

    STRING: 10090.ENSMUSP00000049308

    UniGene: Mm.331218