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  4. Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 22 (Usp22)

Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 22 (Usp22)

  • 中文名称：
    小鼠Usp22重组蛋白
  • 货号：
    CSB-YP685629MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Usp22重组蛋白
  • 货号：
    CSB-EP685629MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Usp22重组蛋白
  • 货号：
    CSB-EP685629MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Usp22重组蛋白
  • 货号：
    CSB-BP685629MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Usp22重组蛋白
  • 货号：
    CSB-MP685629MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Usp22
  • Uniprot No.：
  • 别名：
    Usp22; Kiaa1063; Ubiquitin carboxyl-terminal hydrolase 22; EC 3.4.19.12; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-525
  • 氨基酸序列
    MVARPEPEVE AMDAELAVPP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT AEARKRKAKS CVCHVCGIHL NRLHSCLYCV FFGCFTKKHI HDHAKSKRHN LAIDLMYGGI YCFLCQDYIY DKDIEIIAKE EQRKAWKMQG VGEKFSTWEP TKRELELLKH NPKRRKITSN CTIGLRGLIN LGNTCFMNCI VQALTHTPLL RDFFLSDRHR CEMQSPSSCL VCEMSSLFQE FYSGHRSPHI PYKLLHLVWT HARHLAGYEQ QDAHEFLIAA LDVLHRHCKG DDNGKKANNP NHCNCIIDQI FTGGLQSDVT CQVCHGVSTT IDPFWDISLD LPGSSTPFWP LSPGSEGSVV NGESHASGTT TLTDCLRRFT RPEHLGSSAK IKCSGCHSYQ ESTKQLTMKK LPIVACFHLK RFEHSAKLRR KITTYVSFPL ELDMTPFMAS SKESRMNGQY QQPLDSLNND NKYSLFAVVN HQGTLESGHY TSFIRQHKDQ WFKCDDAIIT KASIKDVLDS EGYLLFYHKQ FLEYE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
  • 基因功能参考文献：
    1. Usp22 is the first deubiquitinase reported to regulate both V(D)J recombination and class switch recombination in vivo by facilitating classical non-homologous end joining. PMID: 29520062
    2. high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation. PMID: 26953552
    3. Usp22 deficiency impairs intestinal epithelial lineage specification. PMID: 26431380
    4. USP22 is a transcriptional repressor of the locus encoding the core pluripotency factor sex-determining region Y-box 2 (SOX2) in embryonic stem cells. PMID: 23760504
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C19 family, UBP8 subfamily
  • 组织特异性：
    Highly expressed in brain and weakly in other organs.
  • 数据库链接：

    KEGG: mmu:216825

    STRING: 10090.ENSMUSP00000041263

    UniGene: Mm.30602