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  4. Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog (Coq7)

Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog (Coq7)

  • 中文名称：
    Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog(Coq7),Yeast
  • 货号：
    CSB-YP005806MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog(Coq7),Yeast
  • 货号：
    CSB-EP005806MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog(Coq7),Yeast
  • 货号：
    CSB-EP005806MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog(Coq7),Yeast
  • 货号：
    CSB-BP005806MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Ubiquinone biosynthesis protein COQ7 homolog(Coq7),Yeast
  • 货号：
    CSB-MP005806MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Coq7
  • Uniprot No.：
  • 别名：
    Coq75-demethoxyubiquinone hydroxylase; mitochondrial; DMQ hydroxylase; EC 1.14.13.-; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    35-217
  • 氨基酸序列
    HSSGMT LDNINRAAVD RIIRVDHAGE YGANRIYAGQ MAVLGRTSVG PVIQKMWDQE KNHLKKFNEL MIAFRVRPTV LMPLWNVAGF ALGAGTALLG KEGAMACTVA VEESIANHYN NQIRMLMEED PEKYEELLQV IKQFRDEELE HHDTGLDHDA ELAPAYALLK RIIQAGCSAA IYLSERF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
  • 基因功能参考文献：
    1. Clk1 plays a direct role in dopaminergic neuronal survival via regulating the autophagy-lysosome pathway that may contribute to the pathologic development of Parkinson disease. PMID: 29025968
    2. Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. PMID: 25339443
    3. An enhanced immune response of Mclk1+/- mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging PMID: 23166727
    4. These findings indicate that MCLK1 (also known as Coq7) regulates both coenzyme Q synthesis and distribution within mitochondrial membranes. PMID: 23045551
    5. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues PMID: 21447381
    6. the partial resistance to I/R injury suggests that Mclk1(+/)(-) mutants have an enhanced recovery potential following age-dependant vascular accidents, which correlates well with their longer survival PMID: 20170652
    7. CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA. PMID: 11959146
    8. clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos. PMID: 18343482
    9. Mclk1 has a role in mitochondrial function, energy metabolism and the aging process PMID: 18635541
    10. action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1. PMID: 18927074
    11. Mclk1 heterozygosity does not necessarily protect against atherosclerosis. Moreover, in the presence of hyperlipidemia and chronic inflammation, Mclk1 heterozygosity is incapable of extending lifespan PMID: 19416523
    12. Reduction in COQ7 levels gradually prevents the deterioration of mitochondrial function and associated increase of global oxidative stress that is normally observed in Sod2(+/-) mutants. PMID: 19478076

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  • 亚细胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    COQ7 family
  • 组织特异性：
    Highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney.
  • 数据库链接：

    KEGG: mmu:12850

    STRING: 10090.ENSMUSP00000032887

    UniGene: Mm.20634