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  4. Recombinant Mouse UDP-glucose 4-epimerase (Gale)

Recombinant Mouse UDP-glucose 4-epimerase (Gale)

  • 中文名称：
    小鼠Gale重组蛋白
  • 货号：
    CSB-YP837110MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gale重组蛋白
  • 货号：
    CSB-EP837110MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gale重组蛋白
  • 货号：
    CSB-EP837110MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gale重组蛋白
  • 货号：
    CSB-BP837110MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gale重组蛋白
  • 货号：
    CSB-MP837110MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gale
  • Uniprot No.：
  • 别名：
    Gale; UDP-glucose 4-epimerase; EC 5.1.3.2; Galactowaldenase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; EC 5.1.3.7; UDP-galactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-galactose 4-epimerase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-347
  • 氨基酸序列
    MEKVLVTGGA GYIGSHTVLE LLEAGYSPVV IDNFHNAIRG EDSMPESLRR VQELTGRSVE FEEMDILDQA ALQHLFKKHS FKAVIHFAGL KAVGESVQKP LDYYRVNLTG TIQLLEIMRA HGVKNLVFSS SATVYGNPQY LPLDEAHPTG GCTNPYGKSK FFIEEMIRDL CRADTAWNAV LLRYFNPIGA HASGRIGEDP QGIPNNLMPY VSQVAIGRRE ALNVFGDDYA TEDGTGVRDY IHVVDLAKGH IAALKKLKEQ CGCRTYNLGT GTGYSVLQMV QAMEKASGKK IPYKVVARRE GDVAACYANP SLAHEELGWT AALGLDRMCE DLWRWQKQNP SGFGAQA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
  • 基因功能参考文献：
    1. These studies reveal a new link between hepatic GALE activity and whole-body glucose homeostasis via regulation of hepatic Tff3 expression. PMID: 28877911
    2. results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes. PMID: 23257357
  • 蛋白家族：
    NAD(P)-dependent epimerase/dehydratase family
  • 数据库链接：

    STRING: 10090.ENSMUSP00000099599

    UniGene: Mm.247946