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  4. Recombinant Mouse Twisted gastrulation protein homolog 1 (Twsg1)

Recombinant Mouse Twisted gastrulation protein homolog 1 (Twsg1)

  • 中文名称：
    小鼠Twsg1重组蛋白
  • 货号：
    CSB-YP884114MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Twsg1重组蛋白
  • 货号：
    CSB-EP884114MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Twsg1重组蛋白
  • 货号：
    CSB-EP884114MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Twsg1重组蛋白
  • 货号：
    CSB-BP884114MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Twsg1重组蛋白
  • 货号：
    CSB-MP884114MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Twsg1
  • Uniprot No.：
  • 别名：
    Twsg1; Tsg; Twisted gastrulation protein homolog 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-222
  • 氨基酸序列
    CNKALC ASDVSKCLIQ ELCQCRPGEG NCPCCKECML CLGALWDECC DCVGMCNPRN YSDTPPTSKS TVEELHEPIP SLFRALTEGD TQLNWNIVSF PVAEELSHHE NLVSFLETVN QLHHQNVSVP SNNVHAPFPS DKERMCTVVY FDDCMSIHQC KISCESMGAS KYRWFHNACC ECIGPECIDY GSKTVKCMNC MF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
  • 基因功能参考文献：
    1. Our results show that BMP binding is required for TWSG1-mediated inhibition of osteoclast formation and function, and validate the critical functional regions within the TWSG1 protein for these interactions PMID: 25808976
    2. The goal of this study was to examine whether mice carrying a mutation in a gene encoding Twsg1, which is associated with a low penetrance of holoprosencephaly, are sensitized to retinoic acid teratogenesis. PMID: 25468951
    3. BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. PMID: 23103586
    4. Data show that Bmp4, Bmp7, Gremlin and Twisted gastrulation (Twsg1) are all expressed in the thymus and expression was clearly different for each gene investigated. PMID: 21978004
    5. suggesting that Twsg1 expression in B cells serves to interpret BMP signals on a per-cell basis PMID: 21572028
    6. These results demonstrate that phenotypic variability in Twsg1-/- mice is associated with differential expression of certain developmentally regulated genes, and that craniofacial defects can be partially rescued by reduced p53 levels. PMID: 21549111
    7. TWSG1 overexpression inhibits RANKL-induced osteoclast differentiation PMID: 21328453
    8. TWSG1 appears to be the main regulator of BMP present in CP. PMID: 20493240
    9. Cv2 enhances pro-BMP activity of Tsg. PMID: 19914233
    10. The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. PMID: 12119341
    11. acts as both a BMP-4 agonist in skeletogenesis and a BMP-4 antagonist in T-cell development PMID: 12665593
    12. Tsg-/-;Bmp4+/- compound mutants die at birth and display holoprosencephaly, first branchial arch and eye defects PMID: 14681194
    13. results suggest that twisted gastrulation and chordin are involved in osteoblast differentiation and mineralization by regulating BMP signaling PMID: 15780974
    14. Tsg overexpression inhibits BMP action in stromal and preosteoblastic cells and, accordingly, arrests their differentiation toward the osteoblastic pathway PMID: 15919755
    15. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation PMID: 16905550
    16. endogenous Tsg is required for normal BMP activity in osteoblastic cells in vitro, but it plays a minor role in the regulation of adult bone homeostasis in vivo PMID: 16934545
    17. The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. PMID: 18644438
    18. Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. PMID: 18789316
    19. Twsg1 limits apoptosis in the distal region of the mandibular arch in mice. PMID: 19389368
    20. Twsg1 interferes with BMP-mediated hepcidin expression and may act with GDF15 to dysregulate iron homeostasis PMID: 19414861
    21. A novel and previously uncharacterized role is presented for TWSG1 in inhibiting osteoclastogenesis through regulation of bone morphogenetic proteins activity. PMID: 19419314

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Twisted gastrulation protein family
  • 组织特异性：
    Expressed in lymph node, liver, kidney, and lung. Expression in the kidney was stronger in the medulla than in the cortex, particularly in the cells surrounding the medullary tubules. Expressed in growth plate cartilage of long bones, ribs, and digits and
  • 数据库链接：

    KEGG: mmu:65960

    STRING: 10090.ENSMUSP00000024906

    UniGene: Mm.10153