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  4. Recombinant Mouse Tumor necrosis factor receptor superfamily member 19 (Tnfrsf19), partial

Recombinant Mouse Tumor necrosis factor receptor superfamily member 19 (Tnfrsf19), partial

  • 中文名称：
    小鼠Tnfrsf19重组蛋白
  • 货号：
    CSB-YP888352MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tnfrsf19重组蛋白
  • 货号：
    CSB-EP888352MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tnfrsf19重组蛋白
  • 货号：
    CSB-EP888352MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tnfrsf19重组蛋白
  • 货号：
    CSB-BP888352MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tnfrsf19重组蛋白
  • 货号：
    CSB-MP888352MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tnfrsf19
  • Uniprot No.：
  • 别名：
    Tnfrsf19; Taj; Troy; Tumor necrosis factor receptor superfamily member 19; TRADE; Toxicity and JNK inducer
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death. Isoform 2 and isoform 3 may act as decoy receptors.
  • 基因功能参考文献：
    1. data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration. PMID: 29237753
    2. High TROY expression is associated with glioblastoma cell invasion. PMID: 26559543
    3. TROY negatively modulates remyelination in the central nervous system. PMID: 24749558
    4. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. PMID: 24129566
    5. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells. PMID: 23142137
    6. TROY is expressed in microglia, involved in their migration and targeted by propentofylline. PMID: 22649568
    7. TROY plays some important roles in neurogenesis of embryonic stages. PMID: 12763585
    8. Analysis of expression patterns of eda, edar and tnfrsf19 in mouse embryogenesis. PMID: 12972005
    9. Both mRNA and protein of TROY are detected in the olfactory bulb during embryogenesis; TROY expression is most intense in the inner layer. In the postnatal olfactory bulb, TROY-expressing cells are also detected in the glomerular layer. PMID: 14966863
    10. Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system. PMID: 15694321
    11. Troy, broadly expressed in postnatal and adult neurons, binds to NgR1 and can replace p75 in the p75/NgR1/LINGO-1 complex to activate RhoA in the presence of myelin inhibitors. PMID: 15694322
    12. Data suggest that signaling from TROY regulates neuronal differentiation at least in part. PMID: 16820005
    13. TROY was expressed in uncommitted precursor cells and astroglial lineage cells, suggesting that TROY plays some roles in the regulation of gliogenesis in the adult CNS. PMID: 16870160
    14. Troy protein is expressed in the matrix region of developing hair follicles and may have a subtle function in skin appendage development. PMID: 18202551
    15. TROY was expressed in some specific subsets of glial cells in the olfactory bulb, including OECs, and may play some roles in the developing and adult olfactory system PMID: 18584774
    16. functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways PMID: 18689798

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 组织特异性：
    Highly expressed in adult brain, and in embryos from day 11-17, but not earlier. Detected in embryonic brain and epithelium, and at lower levels in adult heart, lung and liver. In neonatal mice, mainly in hair follicles and neuron-like cells in the cerebe
  • 数据库链接：

    KEGG: mmu:29820

    STRING: 10090.ENSMUSP00000106865

    UniGene: Mm.281356