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  4. Recombinant Mouse Tumor necrosis factor receptor superfamily member 13C (Tnfrsf13c), partial

Recombinant Mouse Tumor necrosis factor receptor superfamily member 13C (Tnfrsf13c), partial

  • 中文名称：
    小鼠Tnfrsf13c重组蛋白
  • 货号：
    CSB-YP884026MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tnfrsf13c重组蛋白
  • 货号：
    CSB-EP884026MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tnfrsf13c重组蛋白
  • 货号：
    CSB-EP884026MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tnfrsf13c重组蛋白
  • 货号：
    CSB-BP884026MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tnfrsf13c重组蛋白
  • 货号：
    CSB-MP884026MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfrsf13c; Baffr; Bcmd; Br3; Tumor necrosis factor receptor superfamily member 13C; B-cell maturation defect; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD antigen CD268
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
  • 基因功能参考文献：
    1. results indicate that the BAFF-BAFFR ligation bridged between microglia and neurons could play a critical neuroprotective role in brain ischemic injuries PMID: 28918255
    2. These findings elucidate a crucial molecular pathway of B cell selection in the earliest phases of activation by identifying a novel link between B cell receptor affinity and BAFF-R signaling towards Mcl-1. PMID: 27762293
    3. B cell-activating factor (BAFF) upregulates CD28/B7 and CD40/CD154 expression, and promotes the interactions between T and B cells in a BAFF receptor-dependent manner. PMID: 27180986
    4. conclude that P44S BAFFR mutation does not hinder BAFFR function or enhance B cell activity in MRL/Lpr and MRL mice and that other susceptibility loci on the MRL background contributed to the hyperactivity of these cells PMID: 27149280
    5. Results from this study suggest blockade of CXCL13 and BAFFR together may be an effective therapeutic strategy in preventing salivary hypofunction and reducing autoantibody titers and sialadenitis in patients with Sjogren's syndrome PMID: 26826598
    6. Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-term survival. PMID: 25630702
    7. In conclusion, BAFFR signaling affects both innate and adaptive immune activation during viral infections. PMID: 25673724
    8. BAFF controls neural cell survival through BAFF receptor. PMID: 23923031
    9. BAFF receptor deficiency limits Murid herpesvirus 4 infection. PMID: 24501409
    10. Although we have found that TACI is dispensable for controlling B. hermsii infection, mice deficient in BAFFR or BAFF exhibit impairment in B. hermsii-specific IgM responses and clearance of bacteremia. PMID: 24218480
    11. tnfrsf13c is dispensable for the development of SLE in NZM mice. PMID: 23334904
    12. Data show that the B cell antigen receptor (BCR) and Igalpha may be required for B cell survival because they function as adaptor proteins in a BAFFR signaling pathway leading to activation of Syk, indicating crosstalk between the two receptors. PMID: 23453634
    13. BAFF downregulates the expression of steatogenesis genes and enhances steatosis in hepatocytes through BAFF-R. PMID: 23318884
    14. BAFF-R deficiency in mice selectively alters mature B2 cell-dependent cellular and humoral immune responses and limits the development of atherosclerosis. PMID: 22426131
    15. Targeting the BAFF-R to specifically reduce atherogenic B2 cell numbers while preserving atheroprotective B1a cell numbers may be a potential therapeutic strategy to reduce atherosclerosis by potently reducing arterial inflammation. PMID: 22238605
    16. Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors. PMID: 22124120
    17. These findings indicate that upregulation of TLR7 may augment BAFF secretion by APC and through ligation of BAFF-R promote autoreactive B cell survival and thus anti-platelet autoantibody production. PMID: 21818370
    18. BLyS receptor expression and downstream signaling were normal in CD22(-/-) B cells, suggesting that CD22 does not directly alter BLyS responsiveness PMID: 20513733
    19. our data indicate that BAFFR and tonic BCR signals cooperate to enable nonautoreactive immature B cells to differentiate into transitional B cells and to be positively selected into the naive B cell repertoire. PMID: 20861359
    20. Polymorphisms at the APOBEC3 and BAFF-R loci influence the production of virus-neutralizing antibodies upon friend virus infection. PMID: 20375169
    21. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22 PMID: 12160734
    22. the ligand binding interface of BAFF/BLyS receptor 3 was investigated and found to reside within a 26 residue core domain PMID: 12387744
    23. BAFF-R is a receptor for the TNF family member ligand, BAFF [review] PMID: 12456020
    24. BAFF-R function is essential at every stage of follicular (and marginal zone) B cell development and homeostasis beginning with the earliest T1 B cell stage. PMID: 12707337
    25. Data suggest that the BAFF receptor-mediated survival signal, provided by phospholipase c-gamma2, is not sufficient to promote B cell maturation. PMID: 12913095
    26. These data demonstrate a multifaceted role for the BAFF pathway in regulating GC progression. PMID: 14557413
    27. BAFF receptor regulates key and nonoverlapping aspects of peripheral B cell survival and development. PMID: 15528355
    28. TACI and BAFF-R are able to transduce signals that result in isotype switching in B cells. PMID: 15630136
    29. the PVPAT sequence of BAFFR not only functions as a key signaling motif of BAFFR but also determines its signaling specificity in the induction of the noncanonical NF-kappaB pathway PMID: 15644327
    30. Canonical NF-kappaB activity can substitute for BAFF-R signals in B cell development and pathogenesis. PMID: 16782029
    31. BR3, which is expressed on all mature B cells, is a specific receptor for the B-cell survival and maturation factor BAFF[br3] PMID: 16840730
    32. Review. BLyS signaling via BR3 is the dominant homeostatic regulator of primary B cell pools. PMID: 16919470
    33. Review. BAFF and its receptor have roles in B cell biology outside of a survival mechanism. These include germinal center maintenance, isotype switching, and regulation of specific B cell surface markers. PMID: 16931038
    34. the BAFF/BAFF receptor system is critical for the development of skin fibrosis in TSK/+ mice PMID: 17581616
    35. BAFF/BAFF receptor survival signals may require both classical (p50 and alternative (p52) NF-kappaB activation. PMID: 17785824
    36. Altered signaling is linked to the development of B cell-mediated autoimmunity. PMID: 18200501
    37. Report bioassay for BAFF based on expression of a mouse BAFF-receptor ectodomain-human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 endodomain fusion receptor in human rhabdomyosarcoma cells. PMID: 18625509
    38. BAFF-induced signaling pathways are mediated by BAFF-R and represent previously unknown arms of I kappa B kinase (IKK)1-dependent signaling, controlling mature B cell homeostasis PMID: 18713867
    39. We propose that in A/WySnJ mice an excess of BAFF per B cell rescues self-reactive B cells through a partially functional BAFF-R in a B-lymphopenic environment. PMID: 19152335
    40. acquisition of resistance to apoptosis during transitional B cell maturation is achieved by integration of B cell receptor and B cell activating factor receptor signals PMID: 19494297
    41. BaffrDelta168-175 deletion mutant lacking the retrotransposon-displaced residues, and a BaffrT170A mutant lacking a critical threonine, supported B cell survival but failed to support optimal CD21/35 expression. PMID: 19815275
    42. B cell receptor (Bcr) and BAFF receptor (BAFF-R) independently and in concert regulate the survival, differentiation, and function of all B cell populations at and beyond early (T1) precursor cells, the earliest transitional differentiation stage. PMID: 19843948

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  • 相关疾病：
    Defects in Tnfrsf13c are a cause of severe B-cell deficiency. B-cell deficient strain A/WySnJ has a 4.7 kb insertion in the BAFFR gene leading to an altered C-terminus. The mutant RNA is not detectable. B-cell lymphopoiesis is normal, but the life span of peripheral B-cells is much reduced.
  • 亚细胞定位：
    Membrane; Single-pass type III membrane protein.
  • 组织特异性：
    Highly expressed in spleen and testis; detected at lower levels in lung and thymus.
  • 数据库链接：

    KEGG: mmu:72049

    STRING: 10090.ENSMUSP00000086564

    UniGene: Mm.240047