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  4. Recombinant Mouse Tumor necrosis factor ligand superfamily member 14 (Tnfsf14), partial

Recombinant Mouse Tumor necrosis factor ligand superfamily member 14 (Tnfsf14), partial

  • 中文名称：
    小鼠Tnfsf14重组蛋白
  • 货号：
    CSB-YP879457MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tnfsf14重组蛋白
  • 货号：
    CSB-EP879457MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tnfsf14重组蛋白
  • 货号：
    CSB-EP879457MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tnfsf14重组蛋白
  • 货号：
    CSB-BP879457MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tnfsf14重组蛋白
  • 货号：
    CSB-MP879457MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfsf14; LightTumor necrosis factor ligand superfamily member 14; CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14; membrane form; Tumor necrosis factor ligand superfamily member 14; soluble form]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production.
  • 基因功能参考文献：
    1. bone marrow cells from Tnfsf14 deficient mice appeared to promote diet-induced obesity, insulin resistance and reduced FGF21 levels in white adipose tissue and liver PMID: 29359470
    2. Blockade of LIGHT markedly suppressed airway smooth muscle hyperplasia and inflammatory responses, which might be modulated through HVEM-NFkappaB or c-JUN pathways. PMID: 29460021
    3. The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas. PMID: 27172975
    4. LIGHT promote myeloid differentiation of Hematopoietic stem/progenitor cells via LIGHT receptor signaling. PMID: 28422285
    5. LIGHT signalling pathway combined with IFN-gamma induces beta cells apoptosis via an NF-kappaB/Bcl2-dependent mitochondrial pathway. PMID: 27241100
    6. Increasing LIGHT expression increased T-cell proliferation, activation, and infiltration, resulting in enhanced tumor-specific immune-mediated tumor regressions in primary tumors and colorectal liver metastases. PMID: 28249900
    7. Together, these results demonstrate that the LIGHT signaling pathway is not only required for inflammatory cytokine production as part of the host response to chlamydial infection, but also influences the differentiation of CD4(+) CD25(+) FoxP3(+) Treg cells, both of which may be essential for control of C. psittaci respiratory tract infection. PMID: 27725282
    8. These results expose the relevance of LIGHT/LTbetaR/HVEM interaction for the potential therapeutic control of the allogeneic immune responses mediated by alloreactive CD8 T cells that can contribute to prolong allograft survival. PMID: 26752542
    9. Mechanistically, intratumoral LIGHT induces pericyte differentiation and normalization via Rho kinase signaling. Minute amounts of LIGHT act in a paracrine fashion to trigger an amplifying cascade involving transforming growth factor beta (TGF-beta) from peri-vascular macrophages. PMID: 26711337
    10. localized overexpression of Tnfsf14 potently enhances muscle regeneration, and that this regenerative capacity of Tnfsf14 is dependent on Akt signaling. PMID: 26720335
    11. LIGHT-HVEM interactions stimulate IL-12 production by DCs during Leishmania donovani infection. Blockade of LIGHT-LTbetaR interactions dramatically enhanced early anti-parasitic immunity. PMID: 21998581
    12. LIGHT controls TSLP to drive pulmonary fibrosis. PMID: 25680454
    13. The tumor necrosis factor superfamily molecule LIGHT promotes keratinocyte activity and skin fibrosis. PMID: 25789702
    14. LIGHT signal pathway is not correlated with protection against Chlamydia muridarum urogenital tract infection. PMID: 26211324
    15. LIGHT protein is rapidly and transiently expressed after T-cell activation, and this expression is stronger on CD8 T cells than on CD4 T cells PMID: 25226173
    16. Chronic wounds in TNFSF14 KO mice could be induced by exacerbating the redox imbalance by further inhibiting the antioxidant enzymes and by infecting the wounds with biofilm-forming bacteria isolated from the chronic wounds that developed naturally in these mice. PMID: 25313558
    17. Tnfsf14(-/-) mice develop more severe colitis than control mice. LIGHT signals through the lymphotoxin beta receptor in the colon to regulate the innate immune response and mediate recovery from intestinal inflammation. PMID: 24560868
    18. Expression of LIGHT on donor cells is not required for disease induction; however, its expression on host cells is a decisive factor to limit disease progression and tissue damage. PMID: 23720813
    19. interaction of LIGHT with LTbetaR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function. PMID: 23355893
    20. LIGHT promoted MSCs differentiation into adipocyte which was confirmed by Oil Red O Staining Assay. Since either MSCs or adipocytes are the major cell population in bone marrow niche, we then suggest that LIGHT regulate bone marrow niche PMID: 22930663
    21. Here we show that deletion of tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT) leads to impaired wounds in mice that have the characteristics of nonchronic and chronic ulcers. PMID: 22564230
    22. LIGHT regulation of Lymph node hypertrophy in the generation of an adaptive immune response PMID: 21572030
    23. expression of tumor necrosis factor superfamily member 14 and lymphotoxin-beta receptor by motoneurons in vivo correlates with the preferential expression of interferon-gamma at disease onset and symptomatic stage in amyotrophic lateral sclerosis mice PMID: 21072055
    24. Trimerization of soluble mLIGHT is essential for its biological activity. PMID: 21400099
    25. LIGHT is expressed on lung inflammatory cells after allergen exposure. LIGHT-deficient mice also show an impairment in fibrosis and smooth muscle accumulation. PMID: 21499267
    26. LIGHT interaction with the LTbetaR plays a critical role in liver inflammation but is not required for LIGHT-mediated adeno-associated virus clearance. PMID: 20498840
    27. LIGHT enhances the expression of SOCS3 during stimulating BMDC maturation. PMID: 17718431
    28. LIGHT could potentiate the proliferation of T lymphocytes and induction of T CD8(+) cells performing by measuring Granzyme B, a specific marker of cell mediated immunity and virus neutralization antibody titer. PMID: 20097089
    29. LIGHT-deficient mice display reduced signs of intestinal inflammation in the model of dextran sodium sulphate-induced colitis PMID: 20067544
    30. T cell to T cell-mediated LIGHT/HVEM-dependent costimulation is a significant component of the host response leading to cardiac allograft rejection PMID: 11901205
    31. LIGHT selectively plays a role in CD8+ T cell activation but is not required for Th cell-dependent humoral responses. PMID: 11994431
    32. targeted disruption causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis PMID: 12070288
    33. LIGHT, signaling via lymphotoxin beta-specific receptor, in supporting the development and maintenance of the lymphoid microenvironment PMID: 12115617
    34. LIGHT, although a ligand, can receive LIGHT cross-linking enhanced p44/42 mitogen-activated protein kinase activation after TCR ligation. This study reveals a new function and signaling event of LIGHT. PMID: 12384428
    35. LIGHT, a new member of the TNF superfamily [review] PMID: 12456019
    36. LIGHT plays a role in negative selection of thymocytes via inducing the apoptosis of thymocytes bearing high affinity T cell receptors. PMID: 12682226
    37. forced expression of LIGHT in the tumor environment induces a massive infiltration of naive T lymphocytes that correlates with an upregulation of both chemokine production and expression of adhesion molecules PMID: 14704792
    38. In graft arterial disease, the LIGHT pathway plays important roles in the regulation not only of T-cell activation but also of SMC proliferation. PMID: 15178556
    39. Inhibition of LIGHT/herpes simplex virus entry mediator and LIGHT/lymphotoxin beta receptor interactions decreases mortality in MHC class I and II disparate graft-vs-host disease. PMID: 15814693
    40. The expression of LIGHT inside tumors leads to rapid rejection in a natural killer-dependent manner. PMID: 16223768
    41. Our studies thus identify a what we believe to be a novel function of soluble LIGHT in vivo and offer a potential target for therapeutic interventions in hepatic inflammatory diseases PMID: 16557300
    42. We identified lymphotoxin (LT) and LIGHT, tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators of key enzymes that control lipid metabolism PMID: 17431181
    43. selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA PMID: 19017933
    44. The inflammatory interaction between LIGHT & PAR-2 may be operating in vivo within an atherosclerotic lesions in ApoE(-) mice. LIGHT/PAR-2-driven inflammation could be a pathogenic loop in atherogenesis. PMID: 19023130
    45. LIGHT/HVEM signaling negatively regulates neurite growth from developing sensory neurons via NF-kappa B inhibition. PMID: 19211867

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.
  • 蛋白家族：
    Tumor necrosis factor family
  • 数据库链接：

    KEGG: mmu:50930

    STRING: 10090.ENSMUSP00000005976

    UniGene: Mm.483369