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Recombinant Mouse Tropomodulin-1 (Tmod1)

  • 中文名称：
    小鼠Tmod1重组蛋白
  • 货号：
    CSB-YP023909MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tmod1重组蛋白
  • 货号：
    CSB-EP023909MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tmod1重组蛋白
  • 货号：
    CSB-EP023909MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tmod1重组蛋白
  • 货号：
    CSB-BP023909MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tmod1重组蛋白
  • 货号：
    CSB-MP023909MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tmod1
  • Uniprot No.：
  • 别名：
    Tmod1; Tmod; Tropomodulin-1; Erythrocyte tropomodulin; E-Tmod
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-359
  • 氨基酸序列
    MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ KDQTTKAPTG PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ KPMDPVLESV TLEPELEEAL ANASDAELCD IAAILGMHTL MSNQQYYQAL GSSSIVNKEG LNSVIKPTQY KPVPDEEPNS TDVEETLERI KNNDPELEEV NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV AFALAEMLKV NKVLKTLNVE SNFISGAGIL RLVEALPHNT SLVELKIDNQ SQPLGNKVEM EIVNMLEKNT TLLKFGYHFT QQGPRLRASN AMMSNNDLVR KRRLADLTGP IIPKCRSGV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
  • 基因功能参考文献：
    1. Tmod1 function in mouse and human erythroblasts, was investigated. PMID: 28729432
    2. distinct F-actin organizations are present in small protrusions versus large paddles. Formation and/or maintenance of large paddle domains depends on a beta2-spectrin-actin network stabilized by Tmod1. alpha-Actinin-crosslinked F-actin bundles are enhanced in absence of Tmod1, indicating altered cytoskeleton organization. PMID: 27537257
    3. TMOD1 expression was upregulated significantly (p<0.05) in OSCC. PMID: 26718916
    4. RNAi depletion of Tmod1 from either wild-type or Tmod4(-/-) muscle fibers leads to thin filament elongation by approximately 15%. PMID: 26586224
    5. The C-terminal extension of Lmod2 and C terminal of Tmod1 are sufficient to produce a filament nucleator. PMID: 26370058
    6. Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle. PMID: 24430868
    7. Role of Tmod1 protein's leucine rich repeat domain in the formation of neurite-like processes PMID: 24746171
    8. Tmods are novel regulators of actomyosin crossbridge formation and muscle contractility, and future investigations and models of skeletal muscle force production must incorporate Tmods. PMID: 24072783
    9. Tmod1 is involved in a functional synergy critical for regulating lens fiber cell geometry, transparency, and mechanical stiffness. PMID: 23144950
    10. Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex. PMID: 22473940
    11. The Tmod1 deletion caused Tmod3 to leave its SR compartment, leading to mislocalization and destabilization of the Tmod3-gamma(cyto)-actin-sAnk1.5 complex. PMID: 21727195
    12. Tmod1-null mice display a mild anemia with features resembling hereditary spherocytic elliptocytosis. PMID: 20585041
    13. Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain. PMID: 20675374
    14. Tmod1 is a novel regulator of skeletal muscle physiology. PMID: 20368620
    15. Data suggest that tropomodulin 1 is required for regulation of actin filament lengths and myofibril maturation, which is critical for heart morphogenesis during embryonic development. PMID: 14657235
    16. Tmod may be involved in the differentiation process in myogenic cells PMID: 15123707
    17. Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation. PMID: 15950601
    18. Cloning and analysis of the putative Tmod1 promoter show that two conserved sequences, one in the 5'-end of the first exon and the other in the intron next to the first exon, are necessary for the basal promoter activity. PMID: 17904105
    19. In adults, expression is restricted to the olfactory bulb, hippocampus, cerebral cortex, basal ganglia, nuclei of brain stem and cerebellum. In neonates, signals in the cortex and caudate putamen increased from days 15 to 40. PMID: 17920339
    20. Tmod1 is not required in erythrocytes for viability, nor do the Tmod1 knockout fragile primitive erythroid cells affect cardiac development, yolk sac vasculogenesis, or viability in the mouse. PMID: 18927466
    21. specific E-Tmod expression in retinal horizontal cells suggests its role in protecting HCs from mechanical damages in certain eye diseases, such as glaucoma PMID: 19382537
    22. Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens. PMID: 19752024

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tropomodulin family
  • 组织特异性：
    Highly expressed in the erythrocyte, heart and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:21916

    STRING: 10090.ENSMUSP00000103402

    UniGene: Mm.249594