Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Tripartite motif-containing protein 29 (Trim29)

Recombinant Mouse Tripartite motif-containing protein 29 (Trim29)

  • 中文名称：
    小鼠Trim29重组蛋白
  • 货号：
    CSB-YP840276MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim29重组蛋白
  • 货号：
    CSB-EP840276MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trim29重组蛋白
  • 货号：
    CSB-EP840276MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim29重组蛋白
  • 货号：
    CSB-BP840276MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim29重组蛋白
  • 货号：
    CSB-MP840276MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim29
  • Uniprot No.：
  • 别名：
    Trim29; Tripartite motif-containing protein 29
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-587
  • 氨基酸序列
    MEGADACRSN GASPEARDTR SPPGPSGSLE NGTKADSKDT KTTNGHSGEV TEGKTLGSAL KSGEGKSGLF SSNEWRRPII QFVESVDDKG SSYFSMDSAE GRRSPYAGLQ LGASKKPPVT FAEKGELRKS IFSEPRKPTV TIVEPGEVRR NSYPRADSSL LARAKSGSEE VLCDSCIGNK QKAVKSCLVC QASFCELHLK PHLEGAAFRD HQLLEPIRDF EARKCPLHGK TMELFCQTDQ TCICYLCMFQ EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDDVE KWQKEKDRIK SFTTNEKAIL EQNFRDLVRE LEKQKEEVRA ALEQREQDAV DQVKVIVDAL DERAKVLHED KQTREQLHNI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL EGEGLGQSLG NCKDDLLNVC MRHVEKMCKA DLSRNFIERN HMENGGDHRY MNSYTSSYGN EWSTPDTMKR YSMYLTPKGG GRTSYQPSSP SRLSKETNQK NFNNLYGTKG NYTSRVWEYT STVQNSEDMP TVQGNSSFSL KGFPSLLRSQ VPKAQPQTWK SGKQTLLSHY RPFYVNKGSG IGSNEAP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
  • 基因功能参考文献：
    1. Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. PMID: 29038422
    2. this study shows that deletion of TRIM29 enhanced macrophage production of type I interferons and protected mice from infection with influenza virus, while challenge of Trim29-/- mice with Haemophilus influenzae resulted in lethal lung inflammation due to massive production of proinflammatory cytokines by macrophages PMID: 27695001
    3. Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. PMID: 26471361
    4. ATDC up-regulates CD44 in mouse and human PanIN lesions via activation of beta-catenin signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT) phenotype characterized by expression of Zeb1 and Snail1. PMID: 25593307
    5. Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein PMID: 20947501
    6. ATDC increases cell proliferation via inhibition of p53 nuclear activities. PMID: 20368352

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Lysosome.
  • 数据库链接：

    KEGG: mmu:72169

    STRING: 10090.ENSMUSP00000034511

    UniGene: Mm.273277