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  4. Recombinant Mouse Tribbles homolog 2 (Trib2)

Recombinant Mouse Tribbles homolog 2 (Trib2)

  • 货号：
    CSB-YP811719MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP811719MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP811719MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP811719MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP811719MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trib2
  • Uniprot No.：
  • 别名：
    Trib2; Tribbles homolog 2; TRB-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-343
  • 氨基酸序列
    MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFEISCYQES LAPCFCLSAH SNINQITEIL LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ EILDHPWFST DFSVSNSGFG AKEACDQLVP DVNMEENLDP FFN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.
  • 基因功能参考文献：
    1. results suggest that Trib2 positively promotes early erythrocyte differentiation and is essential for tolerance to hemolysis. PMID: 27550848
    2. The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin cell destruction. PMID: 28364459
    3. These data indicate that Trib2 has a complex role in the pathogenesis of Notch-driven T-ALL, which may vary between different T-ALL subtypes. PMID: 27191957
    4. we identify the contribution of dysregulated C/EBPalpha and E2F1 to elevated Trib2 expression and leukemic cell survival PMID: 24516045
    5. Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia. PMID: 20410507
    6. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. PMID: 20160349
    7. Data identify Tribbles homolog 2 as an oncogene that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha. PMID: 17097562
    8. Mice reconstituted with HSC cotransduced with HoxA9 and Trib2 had accelerated onset of AML compared to either gene alone PMID: 17988908
    9. Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3. PMID: 18375036
    10. These results suggest that Trb2 plays minimal roles during kidney and mouse development. PMID: 18593568

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily
  • 数据库链接：

    KEGG: mmu:217410

    STRING: 10090.ENSMUSP00000020922

    UniGene: Mm.491136