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  4. Recombinant Mouse Trem-like transcript 2 protein (Treml2), partial

Recombinant Mouse Trem-like transcript 2 protein (Treml2), partial

  • 中文名称：
    小鼠Treml2重组蛋白
  • 货号：
    CSB-YP646612MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Treml2重组蛋白
  • 货号：
    CSB-EP646612MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Treml2重组蛋白
  • 货号：
    CSB-EP646612MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Treml2重组蛋白
  • 货号：
    CSB-BP646612MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Treml2重组蛋白
  • 货号：
    CSB-MP646612MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Treml2
  • Uniprot No.：
  • 别名：
    Treml2; Tlt2; Trem-like transcript 2 protein; TLT-2; Triggering receptor expressed on myeloid cells-like protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
  • 基因功能参考文献：
    1. TREM2 and TREML2 play opposite roles in microglia activation PMID: 27143430
    2. Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells. PMID: 22573805
    3. TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis PMID: 21804015
    4. (+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site. PMID: 20141543
    5. TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation. PMID: 16670310

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected in B-lymphocytes and macrophages. Detected in spleen, lymph nodes, blood, bone marrow and cells from the peritoneal cavity (at protein level).
  • 数据库链接：

    KEGG: mmu:328833

    STRING: 10090.ENSMUSP00000128215

    UniGene: Mm.329104