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  4. Recombinant Mouse Transcription factor HES-5 (Hes5)

Recombinant Mouse Transcription factor HES-5 (Hes5)

  • 中文名称：
    小鼠Hes5重组蛋白
  • 货号：
    CSB-YP010311MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hes5重组蛋白
  • 货号：
    CSB-EP010311MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hes5重组蛋白
  • 货号：
    CSB-EP010311MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hes5重组蛋白
  • 货号：
    CSB-BP010311MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hes5重组蛋白
  • 货号：
    CSB-MP010311MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Hes5; Hes-5Transcription factor HES-5; Hairy and enhancer of split 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-167
  • 氨基酸序列
    MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV QFLTLHAASD TQMKLLYHFQ RPPAPAAPAK EPPAPGAAPQ PARSSAKAAA AAVSTSRQPA CGLWRPW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator.
  • 基因功能参考文献：
    1. Hes5 is expressed in the nascent mesoderm of gastrulating mouse embryos. Hes5 knockdown enhances primitive erythropoiesis in mouse embryonic stem cells. A stage-specific pulse of Hes5 instructs preferential cardiac fate in mouse embryonic stem cells. PMID: 28648899
    2. Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. PMID: 29352015
    3. Hes5 regulates the transition timing between phases for specification of neocortical neurons and between neurogenesis and gliogenesis. PMID: 28851724
    4. the downstream Notch signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta. PMID: 23776410
    5. Data demonstrate that Hes5 levels in the utricle decreased after the application of siRNA and that the number of hair cells in these utricles was significantly larger than following control treatment. PMID: 23439501
    6. Epigenetic silencing of Hes5 leads to neuronal differentiation despite active Notch signaling. PMID: 23160044
    7. Simultaneous overexpression of Hes5 and Sox21 reveals Hes5 as a downstream effector of Sox21 in adult hippocampus neurogenesis. PMID: 22956844
    8. This study suggested that Hes5 expression is serially activated first by Gcms and later by the canonical Notch pathway PMID: 21765423
    9. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. PMID: 20547764
    10. Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain. PMID: 20431123
    11. Hes5-dependent modulation of myelin gene expression involves old players (i.e. Mash1) and novel mechanisms of transcriptional regulation that include cell-specific regulatory loops with transcriptional activators (i.e. Sox10). PMID: 17006542
    12. These results suggest that to ensure an appropriate outcome in the thymus in response to a lower threshold of induced Notch signaling, induction of the additional target Hes5 is required. PMID: 18048645
    13. Absence of Notch-Hes5 signaling in the normal and damaged adult cochlea is correlated with lack of regeneration potential. Its presence in neonatal cochlea and adult vestibular epithelia is associated with a capacity for plasticity or regeneration. PMID: 19373512

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:15208

    STRING: 10090.ENSMUSP00000051118

    UniGene: Mm.137268