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  4. Recombinant Mouse Transcription factor GATA-5 (Gata5)

Recombinant Mouse Transcription factor GATA-5 (Gata5)

  • 中文名称：
    小鼠Gata5重组蛋白
  • 货号：
    CSB-YP009278MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gata5重组蛋白
  • 货号：
    CSB-EP009278MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gata5重组蛋白
  • 货号：
    CSB-EP009278MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gata5重组蛋白
  • 货号：
    CSB-BP009278MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gata5重组蛋白
  • 货号：
    CSB-MP009278MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gata5
  • Uniprot No.：
  • 别名：
    Gata5Transcription factor GATA-5; GATA-binding factor 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-404
  • 氨基酸序列
    MYQSLALAQS PGQGTYADSG AFLHSSGTGS PVFVAPTRMP SMLPYLPSCE PGSQAPALAA HSSWTQAVAA DSSAFGSGSP HPPAAHPPGA TTFPFAHSPP GSGSGGSAGV RDGGAFQGAL LAREQYPTPL GRPMGASYPT TYPAYMSSDV APSWTSGAFD SSILHGLQAR PGGLPGRRTS FVPDFLEEFP GEGRECVNCG ALSTPLWRRD GTGHYLCNAC GLYHKMNGVN RPLVRPQKRL SSSRRSGLCC SNCHTATTTL WRRNSEGEPV CNACGLYMKL HGVPRPLAMK KESIQTRKRK PKNPAKIKGS SGSTANTTAS SPTLLNSESS ATTLKAESSL ASPVCAGPTI TSQASSPADE SLASSHLEFK FEPEDFAFTS SSMSPQAGLS GVLRQETWCA LALA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer.
  • 基因功能参考文献：
    1. GATA5 is expressed in microvascular endothelial cells and its inactivation in mice leads to vascular endothelial dysfunction and hypertension. PMID: 26617239
    2. Gata5 deficiency induces airway hyperresponsiveness, at least in part, by blunting apoE and increasing IL-13 expression. PMID: 24199649
    3. Expression of Gata5 very efficiently promotes cardiomyocyte fate from murine embryonic stem cells. PMID: 23487308
    4. USF1 transactivates GATA5 expression by binding to the E-box in its promoter PMID: 22625849
    5. Results unravel a critical cell-autonomous role for endocardial Gata5 in aortic valve formation and identify GATA5 as a potential gene responsible for congenital heart disease in humans. PMID: 21633169
    6. data reveal that transcription factor GATA5 is required for differentiation of cardiogenic precursors into endothelial endocardial cells PMID: 12163407
    7. collaboration between GATA-6 and GATA-4, or GATA-6 and GATA-5 which can substitute for GATA-4, is involved in the perception of differentiation cues by embryonic stem cells in their determination of endoderm lineage PMID: 16162334
    8. GATA5 is not expressed in Sertoli cells. Transfected GATA5 & GATA4 work together with human AR to activate human PSA transcription. PMID: 18212046
    9. Report alternative promoter and GATA5 transcripts in mouse. PMID: 19779014

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:14464

    STRING: 10090.ENSMUSP00000015771

    UniGene: Mm.388880