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  4. Recombinant Mouse Transcription factor ETV6 (Etv6)

Recombinant Mouse Transcription factor ETV6 (Etv6)

  • 中文名称：
    小鼠Etv6重组蛋白
  • 货号：
    CSB-YP007860MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Etv6重组蛋白
  • 货号：
    CSB-EP007860MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Etv6重组蛋白
  • 货号：
    CSB-EP007860MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Etv6重组蛋白
  • 货号：
    CSB-BP007860MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Etv6重组蛋白
  • 货号：
    CSB-MP007860MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Etv6; Tel; Tel1Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-485
  • 氨基酸序列
    SETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH LPTHLRLQPI YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK EDFRYRSPHS GDVLYELLQH ILKQRKSRML FSPFFPPGDS IHTKPEVLLH QNHDEDNCVQ RTPRTPAESV HHNPPTIELL HRPRSPITTN HRPSPDPEQQ RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS PVENNHCLPS SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY ENFIRWEDKE SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL NIIRKEPGQR LLFRFMKTPD EIMSGRTDRL EHLESQVLDE QTYQEDEPTI ASPVGWPRGN LPTGTAGGVM EAGELGVAVK EETRE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
  • 基因功能参考文献：
    1. Together with similar observations made in human PAX5-ETV6(+) B-ALLs, these data identified PAX5-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development. PMID: 28219927
    2. ETV6 DNA binding inhibition is established by the stability of its inhibitory helix PMID: 26920109
    3. ETV6-SAM domain interface mutations block ETV6-NTRK3-induced cellular transformation PMID: 23798677
    4. the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS domain PMID: 22584210
    5. find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane PMID: 21804605
    6. Cytogenetic study of 33 children with ETV6-RUNX1 positive acute lymphoblastic leukemia predict long term survival. PMID: 19998443
    7. TEL binding to IRF-8 for recruitment of HDAC3 is regulated by gamma-interferon PMID: 12370291
    8. role in accelerating differentiation of Friend erythroleukemia cells PMID: 12527908
    9. the ability of TEL to repress transcription and suppress growth is regulated by sumoylation and nuclear export PMID: 12626745
    10. nucleo-cytoplasmic delocalization of the major isoform of TEL-ETV6 is regulated by V-src PMID: 12893822
    11. ETV6-NTRK3.IRS-1 complex formation through the NTRK3 C terminus is essential for ETV6-NTRK3 transformation PMID: 14668342
    12. establish Tel/Etv6 as a selective and essential regulator of postembryonic hematopoietic stem cells PMID: 15371326
    13. leukemogenic effect of meningioma 1-TEL in our knock-in mice is pleiotropic, and the type of secondary mutation determines disease outcome PMID: 16105979
    14. Data suggest that TEL exerts a tumor suppressive function through augmenting the p53 pathway. PMID: 16828711
    15. alteration of the cellular localization of TEL may be a part of the cellular stress response and re-localization of TEL to the cytoplasm is an important step in the regulation of TEL PMID: 18022807
    16. Leukemia-related ETV6 expands erythroid precursors and stimulates hemoglobin synthesis. PMID: 19302286

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ETS family
  • 数据库链接：

    KEGG: mmu:14011

    STRING: 10090.ENSMUSP00000079818

    UniGene: Mm.269995