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  4. Recombinant Mouse Thyroid hormone receptor beta (Thrb)

Recombinant Mouse Thyroid hormone receptor beta (Thrb)

  • 中文名称：
    小鼠Thrb重组蛋白
  • 货号：
    CSB-YP023514MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Thrb重组蛋白
  • 货号：
    CSB-EP023514MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Thrb重组蛋白
  • 货号：
    CSB-EP023514MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Thrb重组蛋白
  • 货号：
    CSB-BP023514MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Thrb重组蛋白
  • 货号：
    CSB-MP023514MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Thrb; Erba2; Nr1a2; Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-461
  • 氨基酸序列
    MTPNSMTENG LPAWDKQKPR PDRGQDWKLV GMSEACLHRK SHVERRGALK NEQTSPHLIQ ATWTSSIFHL DPDDVNDQSI SSAQTFQTEE KKCKGYIPSY LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKSLH PSYSCKYEGK CIIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED QIILLKGCCM EIMSLRAAVR YDPDSETLTL NGEMAVTRGQ LKNGGLGVVS DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL FPPLFLEVFE D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
  • 基因功能参考文献：
    1. Genetic Repression in Hypothyroidism Is Mediated by Thrb1. PMID: 28923959
    2. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. PMID: 28864529
    3. TRbeta protein, target gene expression, and metabolic adaptive changes can occur in individual tissues without necessarily being reflected by circulating TH and TSH concentrations PMID: 28457184
    4. Using domain exchanges and individual amino acid switches between THRA1 and THRB2, three amino acids were identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1. PMID: 28911178
    5. Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh gene. PMID: 27026086
    6. Data show that TRbeta deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process. PMID: 25612897
    7. Results suggest mutually shared roles for thyroid hormone receptor beta isoforms TRbeta1 and TRbeta2 in cochlear development. PMID: 26241124
    8. Our findings indicated that synergistic signaling of KRAS(G12D) and TRbetaPV led to increased MYC expression. PMID: 25246276
    9. T3 induces FGF21 in cultured hepatocytes and this effect involves direct actions of TRbeta1, which binds a TRE within intron 2 of FGF21. But T3 induced most gene expression in liver independently of FGF21. PMID: 25501997
    10. TRbeta acts as a cytoplasmic, phosphotyrosine-dependent scaffold for the p85 regulatory subunit of PI3K and the Src kinase Lyn in the absence of thyroid hormone. PMID: 24932806
    11. Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII. PMID: 24058409
    12. these data indicate that interactions between NCoR1 and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance. PMID: 24713658
    13. Taken together, the results of this study provide new insights into the mechanisms of transcriptional regulation by TRbeta1 in vivo. PMID: 24288132
    14. Recruitment of the NRF1 and THRB to the promoters of genes. PMID: 24395638
    15. A combination of isoform-specific recruitment and tissue-specific expression of these newly identified coregulator candidates serves to customize TR function for different biological purposes in different cell types. PMID: 23558175
    16. mutation of a single allele of the Thrb gene is sufficient to drive the TSH-simulated hyperplastic thyroid follicular cells to undergo carcinogenesis. PMID: 22919057
    17. Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor beta gene due to activation of Wnt/beta-catenin protein signaling. PMID: 22442145
    18. mutations in thyroid hormone receptor beta were deleterious to tectorial membrane development and led to important alterations in cochlear morphology and loss of cochlear function PMID: 22178950
    19. TRbeta receptors mediate the acute effects produced by transient changes of thyroid hormone concentrations on bone remodeling. PMID: 21594896
    20. The Delta337T mutation on the TRbeta causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice. PMID: 21746794
    21. A role is found for thyroid hormone receptor beta in modulating hippocampal progenitor cell division. PMID: 20959135
    22. a TRbeta mutation promotes the development of mammary hyperplasia via aberrant activation of STAT5 PMID: 21399657
    23. Results suggest that thyroid hormone receptor beta is involved in suppression of the central component of the hypothalamic-pituitary-thyroid axis in acute illness. PMID: 19302190
    24. Together, our data suggest that the action of TH via TRbeta regulates important events of cerebellar ontogenesis contributing to a better understanding of some neuroendocrine disorders. PMID: 20193766
    25. Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling PMID: 20018842
    26. These observations raise the intriguing possibility that nuclear receptor homodimers such as thyroid hormone receptor display preferential binding to the N-CoR corepressor via their specific interactions with interaction domain ID3. PMID: 20006618
    27. TR beta mediates T(3) regulation of UCP1 in BAT and is required for adaptive thermogenesis. PMID: 19906816
    28. The observation of early, frequent, and multiple mechanisms of TRbeta1 inactivation suggests a potential role for this gene in the suppression of breast tumorigenesis. PMID: 11929806
    29. Patterns of liver gene expression governed by TRbeta PMID: 12040013
    30. Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice. PMID: 12145333
    31. The structural consequences of two hTRbeta mutants, residing in the flexible N-terminal portion of the ligand binding domain (LBD), were investigated. These mutants exhibit modestly reduced hormone binding with impaired release of corepressor. PMID: 12511610
    32. TRbeta mainly controls inner ear and retina development, liver metabolism and thyroid hormone levels. PMID: 12591179
    33. Although thyroid hormone receptor(TR) beta is expressed at much lower levels in all regions of the heart than TR alpha 1, expression of strong dominant negative TR beta PV mutant results in decreased contractile function and heart rate. PMID: 12959993
    34. Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis. PMID: 14500358
    35. TRbeta gene could function as a tumor suppressor gene. TRbeta could serve as a novel therapeutic target in thyroid cancer. PMID: 15231697
    36. the unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis PMID: 15601836
    37. TRalpha1(PV) mutants exhibited skeletal hypothyroidism. PMID: 16051666
    38. A mechanism for cross-talk, and potential antagonism, between TR-beta and LXR-alpha is proposed PMID: 16260782
    39. mechanism by which a mutant thyroid hormone receptor acts to activate phosphatidylinositol 3-kinase activity via protein-protein interactions PMID: 16446424
    40. TRbeta transgenic mice exhibit the symptoms of ADHD in the complete absence of thyroid abnormalities. This suggests that even transient perturbations in developmental thyroid homeostasis can have long-lasting behavioral and cognitive consequences. PMID: 16594981
    41. The dominant negative thyroid hormone receptor beta-mutant Delta337T alters PPARalpha signaling in heart. PMID: 16985257
    42. pituitary tumor-transforming 1, an oncogene, is regulated by the liganded TRbeta PMID: 17039256
    43. Novel PV-mediated oncogenic pathway that could contribute to the local tumor progression and metastatic potential of thyroid carcinogenesis. PMID: 17170101
    44. In H4Flox liver, glutamine synthetase (GS), ornithine aminotransferase (OAT) and thyroid hormone-receptor beta1 (TRbeta1) were exclusively expressed in pericentral hepatocytes. PMID: 17256722
    45. Adult TRbeta deficient mice with elevated thyroid stimulating hormone and thyroid hormone levels were osteoporotic with evidence of increased bone resorption. PMID: 17327419
    46. Gene has incorporated several mechanisms into a multifunctional intron control region that regulates developmental induction of the distant promoter. PMID: 17341594
    47. TR beta 2 and S opsin are expressed in cone photoreceptors only. Both are transcribed by E13, and their levels increase with cone genesis. PMID: 17436273
    48. In the adult progeny, TRbeta(+/-) mice born to TRbeta(-/-) dams and, thus, exposed to higher intrauterine TH levels, have greater resistance to TH at the level of the pituitary when stimulated with TRH. PMID: 17690164
    49. Exerts its antiproliferative action through down-regulation of cyclins D1, E and A2 expression. PMID: 18037966
    50. illness-induced serum T3 and T4 and liver D1 decrease takes place despite the absence of thyroid hormone receptor beta. PMID: 18372241

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    KEGG: mmu:21834

    STRING: 10090.ENSMUSP00000022304

    UniGene: Mm.32563