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  4. Recombinant Mouse Testis-expressed protein 19.1 (Tex19.1)

Recombinant Mouse Testis-expressed protein 19.1 (Tex19.1)

  • 中文名称：
    小鼠Tex19.1重组蛋白
  • 货号：
    CSB-YP857505MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tex19.1重组蛋白
  • 货号：
    CSB-EP857505MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tex19.1重组蛋白
  • 货号：
    CSB-EP857505MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tex19.1重组蛋白
  • 货号：
    CSB-BP857505MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tex19.1重组蛋白
  • 货号：
    CSB-MP857505MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tex19.1
  • Uniprot No.：
  • 别名：
    Tex19.1; Tex19; Tex19a; Testis-expressed protein 19.1; mTex19.1; Testis-expressed protein 19A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-351
  • 氨基酸序列
    MCPPVSVRHG ARGMSCLYEA WLYHLVHGEQ TKICFACFKA AFLLNKLYLE MGDWQEEEEE EEEEDADLLE YLSESESESE QEPGPEQDAW RGLGSLYVPQ SVSEGSGVLL PTPVWTQGIL FSIFVPTELF PQEAVPLDLG PEDAEWTQAL PWRLDGLFPC SHQLIPPLTW WDIFDVMPSP GQPVLLELRC HWPLDQTVAQ SWLQDQKFVL LLDSVQSRCH LLSMRVRWVV RTQVQHWQVL LDPGEMWVAH FRKEVGQHGL YHQSLNPWRL SILTASELGM ELLPATCYLW NKGFWVGSFL PWHINMPETW SWEPGERLFI TDATICGTDY HLAQSFLDSH PTPHPLLTLT P
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization. With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination. Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization.
  • 基因功能参考文献：
    1. Here the s show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the LINE-1 (L1) retrotransposon-encoded protein L1-ORF1p, stimulate its polyubiquitylation and degradation, and restrict L1 mobilization. PMID: 28806172
    2. These data suggest that Tex19.1 and Ubr2 are required for mouse spermatocytes to accumulate sufficient Spo11-dependent recombination to ensure that the homology search is consistently successful, and reveal a hitherto unknown genetic pathway promoting meiotic recombination in mammals. PMID: 28708824
    3. While Tex19.1 is not essential in ES cells, it is important for spermatogenesis and for placenta-supported development. PMID: 23674551
    4. Retrotransposon mRNAs are derepressed in Tex19.1(-/-) placentas and that protein encoded by the LINE-1 retrotransposon is upregulated in hypomethylated trophectoderm-derived cells that normally express Tex19.1. PMID: 23364048
    5. Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway. PMID: 21103378
    6. Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and may repress mTex19.1 expression at the translational level.Confirmed by both electrophoretic mobility shift assay and translation assay in Zebrafish embryo detecting the luciferase activity. PMID: 19247806
    7. Tex19.1 repressed transposable genetic elements and maintained genomic stability through successive generations. PMID: 18802469

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in testis, placenta and ovary. Expressed in pluripotent stem cells. In testis, expression is highest in mitotic spermatogonia, decreases as spermatocytes progress through meiosis, and is present at low levels in round spermatids (at protein leve
  • 数据库链接：

    KEGG: mmu:73679

    UniGene: Mm.390423