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  4. Recombinant Mouse Telomeric repeat-binding factor 2-interacting protein 1 (Terf2ip)

Recombinant Mouse Telomeric repeat-binding factor 2-interacting protein 1 (Terf2ip)

  • 中文名称：
    小鼠Terf2ip重组蛋白
  • 货号：
    CSB-YP838675MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Terf2ip重组蛋白
  • 货号：
    CSB-EP838675MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Terf2ip重组蛋白
  • 货号：
    CSB-EP838675MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Terf2ip重组蛋白
  • 货号：
    CSB-BP838675MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Terf2ip重组蛋白
  • 货号：
    CSB-MP838675MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Terf2ip
  • Uniprot No.：
  • 别名：
    Terf2ip; Rap1; MNCb-0448; MNCb-0628; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Repressor/activator protein 1 homolog; RAP1 homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-393
  • 氨基酸序列
    AEAMDLGKD PNGPTHSSTL FVREDGSAMS FYVRPSSAKR RLSTLILHGG GTVCRVQEPG AVLLAQPGEA LAEASGDFIS TQYILDCVDR NEKLDLEAYR LGLTEQASDP KPGASTEGST EPEPQPLTGR IAYTDAEDVA ILTYVKENAR SPSSVTGNAL WKAMEKSSLT QHSWQSLKDR YLKHLRGQEH KYLLGNAPVS PSSQKLKRKA EQDPEAADSG EPQNKRAPDL PEEECVKGEI KENGEADNKL FEEAAPEFGE AVVDESPDFE IHITMCDGDP PTPEEDSETQ PDEEEEEPKV STQEVGTAIK VIRQLMEKFN LDLSTVTQAL LKNSGELEAT SSFLESGRRP DGYPIWCRQD DLDLQKDDDD TKNALVKKFG AQNVARRIEF RKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
  • 基因功能参考文献：
    1. Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI. PMID: 27050284
    2. HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation. PMID: 28122813
    3. Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G. PMID: 27531745
    4. Collectively the observations uncover a requirement for Rap1 in maintenance of lens epithelial phenotype and morphogenesis. PMID: 26212757
    5. our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse. PMID: 24967784
    6. RASA3, inhibits platelet activation and provides a link between P2Y12 and activation of the RAP1 signaling pathway. PMID: 25705885
    7. we summarize recent developments in understanding the small G protein RAP1 and its effector RASIP1 as critical mediators of endothelial junction stabilization. PMID: 24622510
    8. Molecular investigation revealed that deletion of RAP1 reduced upregulation of inflammatory cytokine (IL1A), finely regulated the expression of angiogenic factor (VEGF), and antiangiogenic factor (PEDF), following injury for better corneal recovery. PMID: 25574050
    9. Cdk5-mediated serine-phosphorylation of C3G may control Rap1 stability and activity PMID: 23416045
    10. Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. PMID: 23241957
    11. Rap1-Rac1 circuits potentiate platelet activation. PMID: 22075250
    12. Rap1-deficient meiotic telomeres assemble the SUN1 nuclear membrane protein, attach to the nuclear envelope, and undergo bouquet formation. PMID: 20927532
    13. Mice with Rap1 deletion in stratified epithelia were viable but had shorter telomeres and developed skin hyperpigmentation in adulthood. PMID: 20622869
    14. Rap1-mutant mice display defective NF-kappaB activation and are resistant to endotoxic shock. PMID: 20622870
    15. study found Rap1 dispensable for essential functions of TRF2--repression of ATM kinase signaling & NHEJ--& mice lacking telomeric Rap1 were viable & fertile; Rap1 was critical for the repression of homology-directed repair which can alter telomere length PMID: 20339076

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome. Chromosome, telomere.
  • 蛋白家族：
    RAP1 family
  • 数据库链接：

    KEGG: mmu:57321

    STRING: 10090.ENSMUSP00000052170

    UniGene: Mm.213064