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  4. Recombinant Mouse Telomerase Cajal body protein 1 (Wrap53)

Recombinant Mouse Telomerase Cajal body protein 1 (Wrap53)

  • 中文名称：
    小鼠Wrap53重组蛋白
  • 货号：
    CSB-YP851813MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Wrap53重组蛋白
  • 货号：
    CSB-EP851813MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Wrap53重组蛋白
  • 货号：
    CSB-EP851813MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Wrap53重组蛋白
  • 货号：
    CSB-BP851813MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Wrap53重组蛋白
  • 货号：
    CSB-MP851813MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Wrap53
  • Uniprot No.：
  • 别名：
    Wrap53; Tcab1; Wdr79; Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein antisense to TP53 gene homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-532
  • 氨基酸序列
    MKTSEERLLA PDSLPPDLAP APVPQGSPAE KNTDFEPVPP PCGGDDQPQL ATDPVASLVV SQELQQGDSV PLEVEFNTSS ELSPGIEEQD VSEHASLPGE ETNLPELESG EATEGVSEER AEVDEGDTFW TYSFSQVPRY LSGSWSEFST RSENFLKGCK WAPDGSCILT NSADNVLRIY NLPPELYSEQ EQVDYAEMVP VLRMVEGDTI YDYCWYSLMS STQPDTSYVA SSSRENPIHI WDAFTGELRA SFRAYNHLDE LTAAHSLCFS PDGSQLFCGF NRTVRVFSTS RPGRDCEVRA TFAKKQGQSG IISCIAFSPS QPLYACGSYG RTIGLYAWDD GSPLALLGGH QGGITHLCFH PDGNLFFSGA RKDAELLCWD LRQPGHLLWS LSREVTTNQR IYFDLDPSGQ FLVSGNTSGV VSVWDISGAL SDDSKLEPVV TFLPQKDCTN GVSLHPTLPL LATASGQRVF PEPTNSGDEG ELELELPLLS LCHAHPECQL QLWWCGGGPD PSSPVDDQDE KGQRRTEAVG MS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localization to Cajal body. During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity. In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies. Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks. Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ).
  • 基因功能参考文献：
    1. Overexpression of WDR79 in non-small cell lung cancer is linked to tumor progression. PMID: 26849396
  • 亚细胞定位：
    Nucleus, Cajal body. Chromosome, telomere. Chromosome.
  • 数据库链接：

    KEGG: mmu:216853

    STRING: 10090.ENSMUSP00000047825

    UniGene: Mm.31586