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  4. Recombinant Mouse T-cell ecto-ADP-ribosyltransferase 1 (Art2a)

Recombinant Mouse T-cell ecto-ADP-ribosyltransferase 1 (Art2a)

  • 货号：
    CSB-YP323818MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP323818MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP323818MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP323818MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP323818MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Art2a
  • Uniprot No.：
  • 别名：
    Art2a; Art2a-ps; Rt6-1; Rt6.1; T-cell ecto-ADP-ribosyltransferase 1; EC 2.4.2.31; ADP-ribosyltransferase 2a pseudogene; ADP-ribosyltransferase C2 and C3 toxin-like 2; ARTC2; Mono(ADP-ribosyl)transferase 2A; NAD(+) glycohydrolase; EC 3.2.2.5; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1; T-cell differentiation marker Rt6 homolog 1; T-cell mono(ADP-ribosyl)transferase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-258
  • 氨基酸序列
    LAVPFMLDMA PNAFDDQYEG CVEDMEKKAP QLLQEDFNMN EELKLEWEKA EIKWKEIKNC MSYPAGFHDF HGTALVAYTG NIHRSLNEAT REFKINPGNF HYKAFHYYLT RALQLLSDQG CRSVYRGTNV RFRYTGKGSV RFGHFASSSL NRSVATSSPF FNGQGTLFII KTCLGAHIKH CSYYTHEEEV LIPGYEVFHK VKTQSVERYI QISLDSPKRK KSNFNCFYSG STQAANVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has both ADP-ribosyltransferase activity and thiol-dependent NAD(+) glycohydrolase activity.
  • 基因功能参考文献：
    1. NAD induces calcium elevation and astrocyte death by an ART2 and P2X7-mediated mechanism. PMID: 22781627
    2. ART2a is required for ADP-ribosylation of cell surface proteins PMID: 12370300
    3. CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2. PMID: 15749861
    4. Transfer of a genetically disrupted CD38 allele into the autoimmune diabetes-prone NOD/Lt background accelerated diabetes onset in both sexes, whereas transfer of a disrupted ART2a/b complex had no effect. PMID: 16585549
    5. identify ART2.1 as a new candidate for linking autocrine/paracrine activation of inflammatory macrophages to the release of NAD, a critical intracellular metabolite PMID: 17947697
    6. Extracellular nicotinamide adenine dinucleotide (NAD) acts via ART2.1 to regulate P2X7 purinergic receptor-dependent inflammatory responses in murine macrophages. PMID: 19542469

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  • 相关疾病：
    A subset of Rt6+ regulatory T-cells may confer protection to autoimmune disease, and failure to develop this subset may result in enhanced susceptibility for autoimmune disease.
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Arg-specific ADP-ribosyltransferase family
  • 组织特异性：
    Expressed in spleen, intestine and thymus.
  • 数据库链接：

    KEGG: mmu:11871

    UniGene: Mm.439746