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  4. Recombinant Mouse Synaptosomal-associated protein 23 (Snap23)

Recombinant Mouse Synaptosomal-associated protein 23 (Snap23)

  • 中文名称：
    小鼠Snap23重组蛋白
  • 货号：
    CSB-YP021871MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Snap23重组蛋白
  • 货号：
    CSB-EP021871MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Snap23重组蛋白
  • 货号：
    CSB-EP021871MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Snap23重组蛋白
  • 货号：
    CSB-BP021871MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Snap23重组蛋白
  • 货号：
    CSB-MP021871MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Snap23
  • Uniprot No.：
  • 别名：
    Snap23; Sndt; Synaptosomal-associated protein 23; SNAP-23; Syndet; Vesicle-membrane fusion protein SNAP-23
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-210
  • 氨基酸序列
    MDNLSPEEVQ LRAHQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE QLNRIEEGMD QINKDMREAE KTLTELNKCC GLCICPCNRT KNFESGKNYK ATWGDGGDNS PSNVVSKQPS RITNGQPQQT TGAASGGYIK RITNDAREDE MEENLTQVGS ILGNLKNMAL DMGNEIDAQN QQIQKITEKA DTNKNRIDIA NTRAKKLIDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
  • 基因功能参考文献：
    1. PKM2 promotes tumor cell exosome release via phosphorylating protein SNAP23. PMID: 28067230
    2. These results demonstrate opposing roles for SNAP23 in the secretion mechanisms of the endocrine and exocrine pancreas. PMID: 27697926
    3. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. PMID: 26182382
    4. these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis. PMID: 26266817
    5. Data indicate that acute depletion of synaptosomal-associated protein 23 (SNAP-23) in fibroblasts leads to rapid apoptotic cell death. PMID: 25706117
    6. Use of neurons from double-knock-out (SNAP-25, synaptotagmin-7) mice in combination with viral transduction showed that SNAP-23-driven release is triggered by endogenous synaptotagmin-7 PMID: 25422940
    7. Results suggest that Plin2 inhibits glucose uptake by interacting with, and regulating cellular targeting of SNAP23 to lipid droplets. PMID: 24040030
    8. morphine suppresses TLR4-induced TNF release in mast cells, preventing the IKK-dependent phosphorylation of SNAP-23, which is necessary for TNF exocytosis, and this inhibition correlates with the formation of a beta-arrestin-2/TRAF6 complex PMID: 23960234
    9. We report the regulation of platelet secretion via phosphorylation of SNAP-23 at Ser95. PMID: 23613522
    10. Results suggest that phagosomal SNAP-23 is one of the key players regulating the phagosomal environment in macrophages. PMID: 23087210
    11. We concluded that the SNARE protein SNAP23 mediates cAMP-stimulated renin release. PMID: 23269646
    12. SNAP23 display robust and ubiquitous pattern of expression in adult hippocampal astrocytes and are therefore likely to be molecularly associated in the core SNARE complex underlying regulated exocytosis in these cells. PMID: 21656854
    13. By altering the levels of individual components of the VAMP3/Stx4/SNAP23 complex we show here that this SNARE complex regulates efficient macrophage adhesion, spreading and migration on fibronectin. PMID: 21586284
    14. These data reveal a critical role for SNAP-23 during embryogenesis. PMID: 21479242
    15. SNAP-23, but not SNAP-25, is important for the functional regulation of postsynaptic glutamate receptors. PMID: 20118925
    16. the majority of SNAP-23 is associated with non-caveolar, cholesterol-rich lipid rafts PMID: 12376543
    17. Palmitoylated peptides from the cysteine-rich domain of this protein cause membrane fusion depending on peptide length, position of cysteinees, and extent of palmitoylation. PMID: 12551899
    18. Interacts with tomosyn and plays a role in insulin-stimulated GLUT4 translocation. PMID: 12832401
    19. Overexpression of SNAP-23 resulted in a distinct phenotype; SNAP-23 did not support a standing pool of primed secretory vesicles. PMID: 12859899
    20. different raft-targeting signals within SNAP-25 and SNAP-23 are likely important for fine-tuning the exocytic pathways in which these proteins operate PMID: 15542596
    21. addition of PIP2 to Stx4/SNAP23 vesicles inhibited the fusion reaction, and its addition to VAMP2 vesicles was stimulatory PMID: 17001002
    22. These results suggest that IKK2 phosphorylation of SNAP-23 leads to degranulation and anaphylactic reactions. PMID: 18692471
    23. Data show that in VAMP-8-deficient cells constitutive vesicular trafficking mechanisms are perturbed as indicated by increased SNARE complex formation between VAMP-3 and SNAP-23. PMID: 19274433
    24. ablation of SNAP23 using siRNA reduced complex formation and beta oxidation, which suggests that the lipid droplets-mitochondria complex is functional in the cell. PMID: 19524684

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane.
  • 蛋白家族：
    SNAP-25 family
  • 组织特异性：
    Expressed in non-neuronal tissues.
  • 数据库链接：

    KEGG: mmu:20619

    STRING: 10090.ENSMUSP00000112138

    UniGene: Mm.245715