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  4. Recombinant Mouse Suppressor of cytokine signaling 1 (Socs1)

Recombinant Mouse Suppressor of cytokine signaling 1 (Socs1)

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  • 中文名称：
    小鼠Socs1重组蛋白
  • 货号：
    CSB-EP022388MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Socs1; Cish1; Ssi1; Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    28.7 kDa
  • 表达区域：
    1-212aa
  • 氨基酸序列
    MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma (IFNG) mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
  • 基因功能参考文献：
    1. The present work shows the role of SOCS1 in murine melanoma development and the potential of SOCS1-silenced tumor cells in raising an effective anti-melanoma immune response. PMID: 28079159
    2. Feeding Guar gum fiber increases SOCS-1, TLR2 and dectin-1 expression in dextran sodium sulfate administered and normal mice. PMID: 28608623
    3. SOCS1 attenuates migration and invasion properties of hepatocellular carcinoma cells at least partly via modulation of MET-mediated epithelial-mesenchymal transition, and controls invasive tumor growth. PMID: 29085209
    4. Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type. PMID: 28901399
    5. these findings suggest that SOCS-1 may exert its protective effect in acute lung injury by rescuing epithelial sodium channel alpha-subunit expression via suppression of ASK-1. PMID: 27058411
    6. loss of SOCS1 in CD11c+ cells skewed the balance of immune response to infection by increasing innate responses while decreasing antigen-specific adaptive responses to infectious antigens PMID: 29150567
    7. MiRNA sponges against miR-19 or miR-155 inhibit the functions of these miRNAs and potentiate the induction of SOCS1 and p53 in mouse leukemia cells and in human myeloma cells. PMID: 26841929
    8. IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 or USP18. PMID: 28900038
    9. Study conclude that under pro-proliferative cytokine stimulation at the onset of myeloproliferative diseases SOCS1 acts as a tumor suppressor, while under anti-proliferative conditions it exerts oncogenic function. PMID: 28753604
    10. results indicate that SOCS1 is one of the essential molecules that maintain regulatory T cell stability, particularly under the inflammatory conditions in which APCs are highly activated PMID: 28550203
    11. The Stat3 exerts its activity through the induction of miR- 155, which suppresses suppressor of cytokine signaling (SOCS)1. PMID: 27183599
    12. miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-alpha in atherogenesis. PMID: 27843203
    13. TLR8 coupling with SOCS-1 inhibits TLR7-mediated antiviral immunity during WNV infection in mice. PMID: 27798161
    14. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway PMID: 28258213
    15. this study shows that genetic modification of dendritic cells with SOCS1 affects their activation and maturation, inhibits T-cell proliferation and induces hypo-responsiveness, and prolongs islet allograft survival PMID: 28215626
    16. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 signaling. PMID: 27236107
    17. Kdm5a associates with p50 and binds to the Socs1 promoter region in resting natural killer cells. PMID: 27050510
    18. The miR-155 inhibitor relieves liver injury by enhancing the expression of SOCS1 and inactivating JAK/STAT signaling. PMID: 26251957
    19. NOS1-derived nitric oxide promotes NF-kappaB transcriptional activity through inhibition of Socs1.Cys147 and Cys179 are essential for SOCS1 nitrosation and proteasomal degradation. PMID: 26324446
    20. mir-155 deficiency attenuates liver ischemia-reperfusion injury through upregulation of SOCS1, which is associated with promotion of M2 macrophage and inhibition of Th17 differentiation PMID: 25611689
    21. Findings indicate that SOCS1 mediates its tumor suppressor functions, at least partly, by binding to MET and interfering with downstream signaling pathways as well as by promoting the turnover of the activated MET receptor. PMID: 25728680
    22. increased expression of SOCS-1 in the lungs of mice significantly protects against hyperoxic lung injury. PMID: 25850028
    23. Overexpression of SOCS1 in transgenic rat eyes attenuated ocular HSV-1 infection PMID: 24993154
    24. negative regulator of cell differentiation and phagocytosis in bone marrow-derived dendritic cells PMID: 25381480
    25. Axl promotes STAT1 signaling via inhibition of SOCS1 in activated smooth muscle cells in vein graft remodeling. PMID: 26276821
    26. targeting SOCS proteins, predominantly SOCS1, to suppress pathological mechanisms involved in atheroma plaque progression and destabilization could be an interesting anti-atherosclerotic strategy PMID: 25604439
    27. While SOCS1 expression in adaptive immune cells is sufficient to inhibit antiviral immunity, SOCS1 in innate/stromal cells is responsible for aggravated lung injury. PMID: 25500584
    28. miR-155 controls the outcome of the the germinal center reaction by modulating its initiation (Aicda) and termination (Socs1/p53 response). PMID: 25645925
    29. these data imply that suppression of IFN-lambda signaling by virus-induced SOCS-1 causes an adaptive increase in IFN-lambda expression by host to protect cells against the viral infection PMID: 24391501
    30. The Socs1 suppresses tumor formation in mammary glands by preventing the natural developmental function of a growth factor signaling pathway from becoming pro-oncogenic. PMID: 24037089
    31. This study is the first to provide evidence that SOCS1 is involved in the regulation of neurogenesis. PMID: 24557021
    32. These data demonstrate an important role for miR-155 in promoting staphylococcal enterotoxin b induced inflammation in the lungs through Socs1 suppression. PMID: 24778118
    33. SOCS1 prevents GA progression by preserving endothelial function and attenuating cytokine-induced adhesion molecule expression in vascular endothelium. PMID: 23994402
    34. These findings underscore the importance of SOCS1 in regulating potentially skin-reactive cytotoxic T lymphocytes, which could get activated under conditions that promote Ag-nonspecific, cytokine-driven proliferation. PMID: 23443260
    35. These data indicate that IL-30 can provide critical protection against macrophage-mediated liver inflammation through anti-apoptotic, anti-oxidant, and anti-inflammatory activities PMID: 23583238
    36. SOCS1 expression in DCs was down-regulated by 80% after Len-SOCS1-shRNA lentivirus infection. PMID: 23643168
    37. Loss of SOCS-1 in the low-density lipoprotein receptor deficient murine model of atherosclerosis resulted in a complex, systemic and ultimately lethal inflammation. PMID: 23300554
    38. miR-155 enhanced Treg and Th17 cells differentiation and IL-17A production by targeting SOCS1. PMID: 23091595
    39. Progesterone suppresses TLRs-triggered immune response by regulating miR-155. The decreased miR-155 contributes to inhibit TLR-induced IL-6 and IFN-beta via increased SOCS1 expression. PMID: 22546503
    40. miR-155 modulates TNF-alpha-regulated osteogenic differentiation by targeting SOCS1. PMID: 22634176
    41. miR-155, an IFN-beta-induced miRNA, mediated the suppressive effect of IFN-beta on osteoclast differentiation by targeting SOCS1 and MITF, two essential regulators of osteoclastogenesis PMID: 22771905
    42. High level of IL-10 within tumour microenvironment compromises Socs1-silenced dendritic cell vaccine functions. PMID: 22230748
    43. Socs1 accelerates the onset of Flt3-internal tandem duplication - induced myeloproliferative disease by promoting the escape from external cytokine control. PMID: 22517899
    44. Our findings suggest that SOCS1 DNA administration has considerable therapeutic potential in individuals with autoimmune myocarditis and dilated cardiomyopathy PMID: 22798678
    45. SOCS1 is expressed via a new, NF-kappaB-independent pathway in Dectin-1-triggered murine bone marrow macrophages and influences Toll-like receptor cross-talk and T cell priming. PMID: 22547696
    46. Toll-like receptor 2-mediated signalling is negatively regulated by SIGNR1-mediated signalling in dendritic cells, possibly through suppressor of cytokine signalling-1-mediated degradation of the MyD88-adaptor-like protein. PMID: 21899704
    47. Socs1(-/-)Ifng(-/-) mice displayed accelerated liver regeneration with increased DNA synthesis compared to Ifng(-/-) and wild type mice. PMID: 21703184
    48. results exemplify the negative role played by SOCS1 during T cell priming and effector functions during M. tuberculosis infection PMID: 21537342
    49. miR-155 had a pro-inflammatory role in microglia and was necessary for the progression of the immune response through the modulation of SOCS-1. PMID: 22043967
    50. SOCS1 is not only a feedback inhibitor of inflammation but also a critical molecular switch that tunes key signaling pathways to effectively program different sides of the macrophage balance PMID: 21628332

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  • 亚细胞定位：
    Nucleus. Cytoplasmic vesicle.
  • 蛋白家族：
    SOCS1 family
  • 组织特异性：
    High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells.
  • 数据库链接：

    KEGG: mmu:12703

    STRING: 10090.ENSMUSP00000038121

    UniGene: Mm.130