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  4. Recombinant Mouse Succinate receptor 1 (Sucnr1), partial

Recombinant Mouse Succinate receptor 1 (Sucnr1), partial

  • 中文名称：
    小鼠Sucnr1重组蛋白
  • 货号：
    CSB-YP022921MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sucnr1重组蛋白
  • 货号：
    CSB-EP022921MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sucnr1重组蛋白
  • 货号：
    CSB-EP022921MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sucnr1重组蛋白
  • 货号：
    CSB-BP022921MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sucnr1重组蛋白
  • 货号：
    CSB-MP022921MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sucnr1; Gpr91; Succinate receptor 1; G-protein coupled receptor 91
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for succinate.
  • 基因功能参考文献：
    1. Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1. PMID: 28736181
    2. Succinate functions as an extracellular ligand through binding to its specific receptor on osteoclastic lineage cells and stimulates osteoclastogenesis in vitro and in vivo. Strategies inhibiting Sucnr1 activation inhibit osteoclastogenesis. PMID: 28561074
    3. activation of SUCNR1 in macrophages is important for both infiltration and inflammation of adipose tissue in obesity PMID: 28382382
    4. This study shows that metformin can attenuate activation of HSCs by activating the AMPK pathway and inhibiting the succinate-GPR91 pathway. Metformin has therapeutic potential for treating steatohepatitis and liver fibrosis. PMID: 29278707
    5. This study reports the expression of GPR91 on mouse and human mast cells and reveals a hyperactive behavior of mouse Sucnr1-/- mast cells in a mechanistic in vivo model of skin inflammation. PMID: 27527650
    6. Sucnr1 knockout mice had increased energy expenditure, less white adipose tissue, and improved glucose buffering compared with controls. They became progressively hyperglycemic and failed to secrete insulin. Sucrn1 may be a sensor for dietary energy. PMID: 25352636
    7. These findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry age-related macular degeneration. PMID: 23833031
    8. GPR91 is expressed in the retinal pigment epithelium with specific localization to the apical membrane, indicating that succinate in the subretinal space serves as the GPR91 agonist PMID: 21357408
    9. SUCNR1 is located in the luminal membrane of macula densa cells of the juxtaglomerular apparatus in close proximity to renin-producing granular cells, the cortical thick ascending limb, and cortical and inner medullary collecting duct cells. PMID: 19776718
    10. GPR91, a previously orphan G-protein-coupled receptor, functions as a receptor for the citric acid cycle intermediate succinate PMID: 15141213
    11. Release of the prohypertensive hormone renin by the kidney, triggered by high levels of glucose, is mediated by a succinate / GPR91 paracrine signaling cascade in the glomerular endothelium. PMID: 18535668
    12. Macul densa cells can sense alterations in local tissue metabolism via accumulation of tubular succinate and GPR91 signaling. PMID: 19389848

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Predominantly expressed in the kidney (proximal and distal tubules and the juxtaglomerular apparatus). Weakly expressed in liver, spleen and small intestine.
  • 数据库链接：

    KEGG: mmu:84112

    STRING: 10090.ENSMUSP00000029326

    UniGene: Mm.125110